Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source
Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
Le marché des stupéfiants dans une société mondialisée / Drug trafficking in globalized society [PDF]
Rivista di Criminologia, Vittimologia e Sicurezza, 2010 International co-operation treaties exist for decades, as well as the international drug traffic. However, they did not yet succeed in efficiently fighting international drug trafficking.
Brochu Serge, Perras Chantal
doaj
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Il traffico di stupefacenti. Strategie di contrasto / Le trafic de stupéfiants. Stratégies de répression / Drug trafficking. Repressive strategies [PDF]
Rivista di Criminologia, Vittimologia e Sicurezza, 2010 This article considers strategies against drugs trafficking. These strategies can be divided into prohibition strategies and anti-prohibition strategies: the first one, according to international conventions, is better the second one.
Zincani V.
doaj
International Human Trafficking: Measuring Clandestinity by the Structural Equation Approach
Social Inclusion, 2017 Worldwide human trafficking is the third most often registered international criminal activity, ranked only after drug and weapon trafficking. This article focusses on three questions: 1) How can human trafficking be measured?
Alexandra Rudolph, Friedrich Schneider
doaj +1 more source
Perceived Normalization of Drug Trafficking and Adolescent Substance Use on the US-Mexico Border. [PDF]
J Drug Issues, 2022 Valdez ES +5 more
europepmc +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Extending borders of knowledge: gendered pathways to prison in Thailand for international cross border drug trafficking. [PDF]
Psychiatr Psychol Law, 2021 Jeffries S +3 more
europepmc +1 more source