Results 61 to 70 of about 2,023,961 (292)
GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
FEBS Open Bio, EarlyView.GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source
, 2023 This fact sheet contains information about sex ...
South Carolina Human Trafficking Task Force
core
War Zone Acapulco: Urban Drug Trafficking in the Americas
Contexto InternacionalAcapulco epitomises the (in)security of urban zones in the Americas whose geographical, political and economic divisions are exacerbated by the political economy and geopolitics of drug trafficking, as well as by militarised attempts to fight it. Various
Thiago Rodrigues +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez +4 more
wiley +1 more source
Can production and trafficking of illicit drugs be reduced or merely shifted ? [PDF]
The production of cocaine and heroin, the two most important drugs economically, has been concentrated in a small number of poor nations for 25 years. A slightly larger number of developing nations have been affected by large-scale trafficking in these ...
Reuter, Peter
core
FEBS Open Bio, EarlyView.The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen +8 more
wiley +1 more source
Other title: Human trafficking
, 2016 Palm card.; "Mike DeWine, Ohio Attorney General."; "Created: 7/20/2016 ..."--Document properties screen.; "Protecting Ohio's Families."On verso: Recognizing the problem: Sex trafficking ; Labor trafficking ; Report suspicious ...
core
Crack cocaine use and its relationship with violence and HIV
Clinics, 2009 OBJECTIVES: To evaluate crack cocaine use practices, risk behaviors associated with HIV infection among drug users, and their involvement with violence. INTRODUCTION: HIV infections are frequent among drug users due to risky sexual behavior.
Heraclito Barbosa de Carvalho +1 more
doaj +1 more source
FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
Legal perspectives on drug trafficking [PDF]
SSRN Electronic Journal, 2017 The two terms ‘trafficking’ and ‘personal consumption’ provide the conceptual framework for the international drug control regime. Neither term is defined. The principal disagreement behind the consensus reached on drug trafficking in the 1988 Convention was the extent to which conduct related to ‘personal consumption’ should fall within the scope of ...
openaire +1 more source