Results 71 to 80 of about 2,023,961 (292)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

open access: yesAging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

A spatio-temporal analysis of forest loss related to cocaine trafficking in Central America

open access: yesEnvironmental Research Letters, 2017
A growing body of evidence suggests that criminal activities associated with drug trafficking networks are a progressively important driver of forest loss in Central America. However, the scale at which drug trafficking represents a driver of forest loss
Steven E Sesnie   +7 more
doaj   +1 more source

KERJASAMA INDONESIA- MALAYSIA DALAM MENANGANI PEREDARAN NARKOBA DI PERBATASAN

open access: yesDinamika Global, 2020
Indonesia and Malaysia have close ties especially in their land borders, making it easier to access buying and selling that occurs between communities on the border. Especially in trade to drug trafficking that occurs in border areas such as the Entikong-
Ade Priangani   +2 more
doaj   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni   +19 more
wiley   +1 more source

Hidden Resilience in the Life of Adolescents with Involvement in Drug Trafficking

open access: yesPsicologia: Teoria e Pesquisa, 2019
This paper identifies hidden resilience processes among adolescents and young adults who have had involvement in drug trafficking. The participants were 551 adolescents and young people, aged 12-20 years (M = 16.01; SD = 1.548) from both genders, 55.4 ...
Alex Sandro Gomes Pessoa   +3 more
doaj   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Le marché des stupéfiants dans une société mondialisée / Drug trafficking in globalized society [PDF]

open access: yesRivista di Criminologia, Vittimologia e Sicurezza, 2010
International co-operation treaties exist for decades, as well as the international drug traffic. However, they did not yet succeed in efficiently fighting international drug trafficking.
Brochu Serge, Perras Chantal
doaj  

Baseline Neuroinflammation Stratifies TSPO‐PET Response to Disease‐Modifying Therapy in Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate which baseline clinical and imaging characteristics best predict TSPO‐PET‐measurable reduction in glial activation following treatment of multiple sclerosis (MS), to utilize this information for designing more efficient biomarker‐based clinical trials targeting glial activation.
Marlene T. Morch   +5 more
wiley   +1 more source

Drug Trafficking in the Americas [PDF]

open access: yesHispanic American Historical Review, 1996
The Bush Administration's Andean Drug Strategy in Historical Perspective, W. Walker III US-Andean Drug Policy, R. Perl The US Military and the War on Drugs, D. Mabry After San Antonio, B. Bagley The Size of the Illegal Drug Industry, F. Thoumi Drug Trafficking and Society in Colombia, A.
openaire   +1 more source

Perceived Normalization of Drug Trafficking and Adolescent Substance Use on the US-Mexico Border. [PDF]

open access: yesJ Drug Issues, 2022
Valdez ES   +5 more
europepmc   +1 more source

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