Results 241 to 250 of about 158,142 (288)
Hypoxia modulates P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) drug transporters in brain endothelial cells of the developing human blood-brain barrier. [PDF]
HeliyonMughis H +4 more
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Drug Transporters in Drug Efficacy and Toxicity
Annual Review of Pharmacology and Toxicology, 2012 Drug transporters are now widely acknowledged as important determinants governing drug absorption, excretion, and, in many cases, extent of drug entry into target organs. There is also a greater appreciation that altered drug transporter function, whether due to genetic polymorphisms, drug-drug interactions, or environmental factors such as dietary ...
Richard B Kim
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Renal Drug Transporters and Drug Interactions
Clinical Pharmacokinetics, 2017 Transporters in proximal renal tubules contribute to the disposition of numerous drugs. Furthermore, the molecular mechanisms of tubular secretion have been progressively elucidated during the past decades. Organic anions tend to be secreted by the transport proteins OAT1, OAT3 and OATP4C1 on the basolateral side of tubular cells, and multidrug ...
Ivanyuk A, Livio F, Biollaz J, Buclin T
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Renal Transporters in Drug Development [PDF]
Annual Review of Pharmacology and Toxicology, 2013 The kidney plays a vital role in the body's defense against potentially toxic xenobiotics and metabolic waste products through elimination pathways. In particular, secretory transporters in the proximal tubule are major determinants of the disposition of
Sophie L Stocker +2 more
exaly +2 more sources
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Transporter-Mediated Drug–Drug Interactions
Pharmacogenomics, 2011Drug-drug interactions are a serious clinical issue. An important mechanism underlying drug-drug interactions is induction or inhibition of drug transporters that mediate the cellular uptake and efflux of xenobiotics. Especially drug transporters of the small intestine, liver and kidney are major determinants of the pharmacokinetic profile of drugs ...
Fabian, Müller, Martin F, Fromm
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Pharmacogenetics of Drug Transporters
Current Pharmaceutical Design, 2010During the last decade, a greater focus has been given to impact of genetic variation in membrane transporters on the pharmacokinetics and toxicity of numerous therapeutic drugs. While the majority of transporter-related pharmacogenetic research has been in regards to classic genes encoding the outward-directed ATP-binding cassette (ABC) transporters ...
R M, Franke, E R, Gardner, A, Sparreboom
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Current Drug Metabolism, 2004
Any treatment of a pregnant woman with medication (drugs) de facto results in the treatment of her unborn child, even when her unborn child is not the target of drug therapy. This is because, in most instances, the placenta is not a complete barrier to the passage of drugs from the maternal to the fetal compartment.
Jashvant D, Unadkat +2 more
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Any treatment of a pregnant woman with medication (drugs) de facto results in the treatment of her unborn child, even when her unborn child is not the target of drug therapy. This is because, in most instances, the placenta is not a complete barrier to the passage of drugs from the maternal to the fetal compartment.
Jashvant D, Unadkat +2 more
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Membrane transporters in drug development and as determinants of precision medicine [PDF]
Nature Reviews Drug DiscoveryThe effect of membrane transporters on drug disposition, efficacy and safety is now well recognized. Since the initial publication from the International Transporter Consortium, significant progress has been made in understanding the roles and functions ...
Aleksandra Galetin +2 more
exaly +2 more sources
Clinical Infectious Diseases, 1994
The ability of drugs to enter cells and to reach an adequate concentration within the appropriate intracellular compartment may be an important determinant of the efficacy of therapy for infections due to intracellular pathogens. Antibiotics vary considerably in their ability to accumulate within cells.
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The ability of drugs to enter cells and to reach an adequate concentration within the appropriate intracellular compartment may be an important determinant of the efficacy of therapy for infections due to intracellular pathogens. Antibiotics vary considerably in their ability to accumulate within cells.
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2002
A wide variety of transporters are found in the intestine, and are involved in the membrane transport of daily nutrients as well as drugs. These intestinal transporters are located in the brush border membrane as well as basolateral membrane. Each transporter exhibits its own substrate specificity, and some have broader specificities than others.
D M, Oh, H K, Han, G L, Amidon
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A wide variety of transporters are found in the intestine, and are involved in the membrane transport of daily nutrients as well as drugs. These intestinal transporters are located in the brush border membrane as well as basolateral membrane. Each transporter exhibits its own substrate specificity, and some have broader specificities than others.
D M, Oh, H K, Han, G L, Amidon
openaire +2 more sources