Results 241 to 250 of about 2,100,066 (288)
Membrane Transporters in Drug Development and as Determinants of Precision Medicine [PDF]
Nature Reviews Drug DiscoveryThe effect of membrane transporters on drug disposition, efficacy and safety is now well recognized. Since the initial publication from the International Transporter Consortium, significant progress has been made in understanding the roles and functions ...
Noora Sjöstedt +2 more
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Transporters and Renal Drug Elimination
Annual Review of Pharmacology and Toxicology, 2004 Carrier-mediated processes, often referred to as transporters, play key roles in the reabsorption and secretion of many endogenous and xenobiotic compounds by the kidney.
Wooin Lee, Richard Kim
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Transporter-Mediated Drug–Drug Interactions
Pharmacogenomics, 2011Drug-drug interactions are a serious clinical issue. An important mechanism underlying drug-drug interactions is induction or inhibition of drug transporters that mediate the cellular uptake and efflux of xenobiotics. Especially drug transporters of the small intestine, liver and kidney are major determinants of the pharmacokinetic profile of drugs ...
Fabian, Müller, Martin F, Fromm
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Renal Transporters in Drug Development [PDF]
Annual Review of Pharmacology and Toxicology, 2013 The kidney plays a vital role in the body's defense against potentially toxic xenobiotics and metabolic waste products through elimination pathways. In particular, secretory transporters in the proximal tubule are major determinants of the disposition of
Kathleen Giacomini +2 more
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Current Drug Metabolism, 2004
Any treatment of a pregnant woman with medication (drugs) de facto results in the treatment of her unborn child, even when her unborn child is not the target of drug therapy. This is because, in most instances, the placenta is not a complete barrier to the passage of drugs from the maternal to the fetal compartment.
Jashvant D, Unadkat +2 more
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Any treatment of a pregnant woman with medication (drugs) de facto results in the treatment of her unborn child, even when her unborn child is not the target of drug therapy. This is because, in most instances, the placenta is not a complete barrier to the passage of drugs from the maternal to the fetal compartment.
Jashvant D, Unadkat +2 more
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Pharmacogenetics of Drug Transporters
Current Pharmaceutical Design, 2010During the last decade, a greater focus has been given to impact of genetic variation in membrane transporters on the pharmacokinetics and toxicity of numerous therapeutic drugs. While the majority of transporter-related pharmacogenetic research has been in regards to classic genes encoding the outward-directed ATP-binding cassette (ABC) transporters ...
R M, Franke, E R, Gardner, A, Sparreboom
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Brain and the Drug Transporters
2017In the treatment of various central nervous system (CNS) diseases, drugs have to cross the brain barriers (blood–brain barrier and blood–cerebrospinal fluid barrier) and reach effective concentrations in the brain. In some cases, they also have to permeate through the cellular compartments of the brain parenchyma (i.e., astrocytes, microglia ...
GÜLSÜN İNAL, TUĞBA +2 more
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Clinical Infectious Diseases, 1994
The ability of drugs to enter cells and to reach an adequate concentration within the appropriate intracellular compartment may be an important determinant of the efficacy of therapy for infections due to intracellular pathogens. Antibiotics vary considerably in their ability to accumulate within cells.
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The ability of drugs to enter cells and to reach an adequate concentration within the appropriate intracellular compartment may be an important determinant of the efficacy of therapy for infections due to intracellular pathogens. Antibiotics vary considerably in their ability to accumulate within cells.
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2002
A wide variety of transporters are found in the intestine, and are involved in the membrane transport of daily nutrients as well as drugs. These intestinal transporters are located in the brush border membrane as well as basolateral membrane. Each transporter exhibits its own substrate specificity, and some have broader specificities than others.
D M, Oh, H K, Han, G L, Amidon
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A wide variety of transporters are found in the intestine, and are involved in the membrane transport of daily nutrients as well as drugs. These intestinal transporters are located in the brush border membrane as well as basolateral membrane. Each transporter exhibits its own substrate specificity, and some have broader specificities than others.
D M, Oh, H K, Han, G L, Amidon
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Enzymes, Drugs and Transport Phenomena
Protoplasma, 1967Other contributors to this Symposium on Biophysics and Physiology of Biological Transport have dealt with the physicochemical aspects of membrane transport, what the membranes of cells and their organelles look like, how they behave physiologically, and the biochemical interpretation of the transport of isodium and potassium across such structures ...
K H, Beyer, J E, Baer
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