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Drug transport and drug resistance in African trypanosomes
Drug Resistance Updates, 2003Drug resistance in African trypanosomes has been studied for almost a hundred years. Beginning with Paul Ehrlich's work that led to the chemoreceptor hypothesis, reduction of net drug uptake has emerged as the most frequent cause of resistance. This review, therefore, focuses on trypanosomal drug transporter genes.
Mäser P, Lüscher A, Kaminsky R
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Importance of Drug Transporters in Pharmacokinetics and Drug Safety
Toxicology Mechanisms and Methods, 2008ABSTRACT The exact role of transporters in the absorption, distribution, and excretion (ADE) of drugs is still being elucidated; however, current evidence suggests that their role in these processes may be significant. In this review, the role of transporters in the ADE, pharmacology, toxicology, and clinical drug-drug interactions (DDIs) of drugs will
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Journal of Clinical Psychopharmacology, 2001
L L, von Moltke, D J, Greenblatt
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L L, von Moltke, D J, Greenblatt
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Transporter-Mediated Drug-Drug Interactions and Their Significance
2019Drug transporters are considered to be determinants of drug disposition and effects/toxicities by affecting the absorption, distribution, and excretion of drugs. Drug transporters are generally divided into solute carrier (SLC) family and ATP binding cassette (ABC) family.
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Membrane transporters in drug development
Nature Reviews Drug Discovery, 2010Donald J Tweedie +2 more
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What do drug transporters really do?
Nature Reviews Drug Discovery, 2014Sanjay K Nigam, Nigam Sanjay K
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Transporters in drug development: advancing on the Critical Path
Nature Reviews Drug Discovery, 2010Shiew-Mei Huang +2 more
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