Results 261 to 270 of about 4,751,257 (301)

Ultrasmall Platinum Nanoparticles for Radiation‐Enhanced Cancer Therapy

Advanced Functional Materials, EarlyView.
This work proposes a nanomedicine‐based strategy to enhance X‐ray radiotherapy for cancer treatment. Ultrasmall Pt‐NPs exhibit catalase‐like activity that may contribute to modulation of the tumor microenvironment and amplify interactions between radiation and biological matter, leading to increased DNA damage.
Miguel Encinas‐Gimenez, Jose I. Garcia‐Peiro, Jose L. Hueso, Eduardo Caleiras, Laura Notario, Felipe Hornos, Pilar Martin‐Duque, Antonio De la Vieja, Jesus Santamaria   +8 more
wiley   +1 more source

Bioactive Conductive Ti3C2Tx‐Ce Hydrogel Facilitates Spinal Cord Injury Repair Through ROS Scavenging and Mitochondrial Regulation

Advanced Functional Materials, EarlyView.
Bioactive conductive Ti3C2Tx‐Ce hydrogels with with scavenging ROS and alleviating neuronal mitochondrial dysfunction are exploited for SCI treatment. This functionality is attributed to interfacial activation modification of Ti3C2Tx with Ce3+ ions to in‐situ form Ce(OH)x‐mediated protective layer, which is beneficial to enabling stable intracellular ...
Weikang Wang, Qing Liu, Ang Lv, Yabin Lin, Jiawei Chen, Ning Ding, Chunlei Zhang, Shuai Zhou, Bo Yuan, Weiwei Zhao, Liming Li, Luping Zhang, Fei Huang   +12 more
wiley   +1 more source

Genetic Variants in the <i>ABCB1</i> and <i>ABCG2</i> Gene Drug Transporters Involved in Gefitinib-Associated Adverse Reaction: A Systematic Review and Meta-Analysis. [PDF]

Genes (Basel)
Morau MV, Seguin CS, Visacri MB, Pincinato EC, Moriel P.   +4 more
europepmc   +1 more source

Atomic Layer Deposition in Transistors and Monolithic 3D Integration

Advanced Functional Materials, EarlyView.
Transistors are fundamental building blocks of modern electronics. This review summarizes recent progress in atomic layer deposition (ALD) for the synthesis of two‐dimensional (2D) metal oxides and transition‐metal dichalcogenides (TMDCs), with particular emphasis on their enabling role in monolithic three‐dimensional (M3D) integration for next ...
Yue Liu, Taoyu Zou, Cheng‐Yan Xu, Liang Zhen, Yang Li, Yong‐Young Noh   +5 more
wiley   +1 more source

Balancing Electrons to Break the Activity‐Selectivity Trade‐Off in H2O2 Electrosynthesis

Advanced Functional Materials, EarlyView.
Carrier‐concentration balancing in CuS is achieved by coupling cobalt dopants with cobalt vacancies, converting CuS from p‐ to n‐type to accelerate 2e− ORR while withdrawing excess carriers to optimize *OOH binding for H2O2 desorption. The catalyst reaches 8.14 mol g−1 h−1 with >84% selectivity in 1.0 M KOH and drives robust electro‐Fenton dye ...
Hangning Liu, Changhui Sun, Luyao Wang, Yuhang Cheng, Yi Xin, Xuyun Guo, Hui Li, Valeria Nicolosi, Yuhai Dou, Peng Li, Tianyi Ma, Jie Wang   +11 more
wiley   +1 more source

Hypoxia modulates P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) drug transporters in brain endothelial cells of the developing human blood-brain barrier. [PDF]

Heliyon
Mughis H, Lye P, Imperio GE, Bloise E, Matthews SG.   +4 more
europepmc   +1 more source

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Membrane transporters in drug development and as determinants of precision medicine

Nature Reviews Drug Discovery
A. Galetin, Kim L. R. Brouwer, D. Tweedie, Kenta Yoshida, Noora Sjöstedt, Lauren M. Aleksunes, Xiaoyan Chu, Raymond Evers, Michael J. Hafey, Yurong Lai, Pär Matsson, Andrew M Riselli, Hong Shen, Alex Sparreboom, M. Varma, Jia Yang, Xinning Yang, S. Yee, Maciej J. Zamek-Gliszczynski, Lei Zhang, Kathleen M. Giacomini   +20 more
semanticscholar   +3 more sources

The RESOLUTE consortium: unlocking SLC transporters for drug discovery

Nature Reviews Drug Discovery, 2020
G. Superti-Furga, Daniel F. Lackner, T. Wiedmer, Álvaro Inglés-Prieto, Barbara Barbosa, E. Girardi, Ulrich Goldmann, Bettina Gürtl, K. Klavins, Christoph Klimek, Sabrina Lindinger, Eva Lineiro-Retes, A. Müller, S. Onstein, G. Redinger, D. Reil, V. Sedlyarov, Gernot Wolf, M. Crawford, R. Everley, D. Hepworth, Shenping Liu, Stephen Noell, M. Piotrowski, R. Stanton, Hui Zhang, Salvatore Corallino, A. Faedo, M. Insidioso, G. Maresca, L. Redaelli, F. Sassone, L. Scarabottolo, M. Stucchi, P. Tarroni, Sara Tremolada, H. Batoulis, Andreas Becker, E. Bender, Yung-Ning Chang, A. Ehrmann, A. Müller-Fahrnow, Vera Pütter, Diana Zindel, Bradford Hamilton, M. Lenter, Diana Santacruz, C. Viollet, C. Whitehurst, K. Johnsson, Philipp Leippe, Birgit U. Baumgarten, Lena Chang, Y. Ibig, Martin J. Pfeifer, Jürgen Reinhardt, Julian Schönbett, P. Selzer, K. Seuwen, Charles Bettembourg, B. Biton, J. Czech, Hélène de Foucauld, Michel Didier, T. Licher, V. Mikol, A. Pommereau, F. Puech, Veeranagouda Yaligara, A. Edwards, B. Bongers, L. Heitman, A. IJzerman, Huub J Sijben, G. V. van Westen, J. Grixti, D. Kell, Farah Mughal, Neil Swainston, Marina Wright-Muelas, T. Bohstedt, N. Burgess-Brown, L. Carpenter, Katharina L. Dürr, J. Hansen, A. Scacioc, Giulia Banci, Claire Colas, Daniela Digles, G. Ecker, Barbara Füzi, Viktoria Gamsjäger, Melanie Grandits, Riccardo Martini, F. Troger, P. Altermatt, C. Doucerain, F. Dürrenberger, V. Manolova, A. Steck, H. Sundström, Maria Wilhelm, C. Steppan   +102 more
semanticscholar   +3 more sources

Protein Abundance of Clinically Relevant Drug Transporters in the Human Liver and Intestine: A Comparative Analysis in Paired Tissue Specimens

Clinical pharmacology and therapy, 2019
Bioavailability of orally administered drugs is partly determined by function of drug transporters in the liver and intestine. Therefore, we explored adenosine triphosphate–binding cassette (ABC) and solute carriers family transporters expression ...
M. Droździk, D. Busch, J. Lapczuk, Janett Müller, M. Ostrowski, M. Kurzawski, S. Oswald   +6 more
semanticscholar   +1 more source

Implication of human drug transporters to toxicokinetics and toxicity of pesticides.

Pest Management Science, 2019
Human membrane drug transporters are recognized as major actors of pharmacokinetics. Pesticides also interact with human drug transporters, which may have consequences for pesticide toxicokinetics and toxicity.
Nelly Guéniche, Arnaud Bruyère, M. Le Vée, O. Fardel   +3 more
semanticscholar   +1 more source