Results 91 to 100 of about 244,483 (261)

Pharmacovigilance in clinical trials [PDF]

Vojnosanitetski Pregled, 2007
Ilić Katarina, Ugrešić Nenad
doaj   +1 more source

Pharmacoepidemiological research of lipid-lowering therapy in ischemic heart disease

Кубанский научный медицинский вестник, 2014
The pharmacoepidemiological study includes a review of the use of lipid-lowering drugs with the main indicators of consumption - defined daily dose (DDD) and prescribed daily dose (PDD).
M. A. Mishchenko, N. N. Chesnokova
doaj  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Optimizing Antifungal Use Through Interdisciplinary Intervention in the Hematology Unit

Journal of Fungi
Invasive fungal infections are frequent complications in patients with hematologic malignancies due to immunosuppression and intensive treatments. In Colombia, limited diagnostic availability, heterogeneous prescribing practices, and emerging antifungal ...
Maria Alejandra Caro Flautero, Maria Camila Rubio, Edgar Fabián Manrique-Hernández, Jeimy Lorena León, Olga Daniela Vega Jiménez, Paola Cristina Álvarez Mantilla, Pilar Rivas-Pinedo, Alejandra Mendoza-Monsalve, Maricel Licht-Ardila, Alexandra Hurtado-Ortiz, Carlos Augusto Solórzano   +10 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Drug Utilization Review Program Newsletter Drug Utilization Review Bulletin

, 2011
In 2009 this publication's title changed from Drug Utilization Review Bulletin to Drug Utilization Review Newsletter This internet resource contains several newsletters issued throughout several ...
Kansas. Department of Health and Environment
core  

Human Albumin Utilization in Patients Admitted to a University-affiliated Hospital in Iran

Journal of Pharmacoeconomics and Pharmaceutical Management, 2018
Background: As an essential human protein and an expensive biological drug, albumin is, in several cases, prescribed without an appropriate indication. This study determined the compatibility of albumin administration with the current standard protocols
Afshin Gharekhani, Hamid Noshad, Soheil Teimouri, Haleh Rezaee, Abasad Gharedaghi, Sepideh Rahigh-Aghsan   +5 more
doaj  

Avaliação de prescrições medicamentosas de um hospital universitário brasileiro

Revista Brasileira de Educação Médica
A prescrição é o ponto de partida para a utilização de medicamentos. O objetivo deste trabalho foi identificar a qualidade das informações presentes nas prescrições das enfermarias de um hospital universitário brasileiro.
Joice Mara Cruciol-Souza, João Carlos Thomson, Douglas Godoy Catisti   +2 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source