Results 71 to 80 of about 244,483 (261)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

Gastroretentive microparticles for drug delivery applications [PDF]

open access: yes, 2011
Many strategies have been proposed to explore the possibility of exploiting gastroretention for drug delivery. Such systems would be useful for local delivery, for drugs that are poorly soluble at higher pH or primarily absorbed from the proximal small ...
Conway, Barbara R   +5 more
core   +1 more source

Benefits of Pharmacist’s Participation on Hospitalist Team

open access: yesActa Medica Iranica, 2016
This study was performed to assess the incidence of medication errors and irrational use of human albumin in two wards of our hospital and also aimed to evaluate the ability of pharmaceutical care center and pharmacists in improving patient care. Albumin
Simin Mahdikhani, Fatemeh Dabaghzadeh
doaj  

Regional variation in the potentially inappropriate first-line use of fluoroquinolones in Canada as a key to antibiotic stewardship? A drug utilization review study. [PDF]

open access: yesBMC Infect Dis, 2021
St-Jean A   +10 more
europepmc   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Iron deficiency anaemia

open access: yesRevista Médica del Hospital General de México, 2016
Iron deficiency anaemia is a public health problem that affects all age groups. In Mexico, it is a common cause of morbidity, and accounts for 50% of cases of anaemia worldwide.
G. Barragán-Ibañez   +2 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Drug utilization studies among ENT patients in various clinical settings: A comprehensive review

open access: yes, 2019
Drug utilization research is thus an all important part of pharmacoepideminology as it explains the extent, nature and determinants of drug exposure. A drug utilization study is a tool for determining the effectiveness of drug use.
Rasool, Shafiqa   +2 more
core   +1 more source

Impact of supply chain disruptions and drug shortages on drug utilization: A scoping review protocol.

open access: yesPLoS ONE
ObjectiveThis proposed scoping review aims to examine studies assessing the impact of drug shortages on population-level drug utilization trends. The objectives of this review are to a) assess which drugs have been studied and describe associated drug ...
Araniy Santhireswaran   +5 more
doaj   +1 more source

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