Results 91 to 100 of about 9,549,304 (358)

Discovery of new chromen-4-one derivatives as telomerase inhibitors through regulating expression of dyskerin

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
A series of new trimethoxyphenyl-4H-chromen derivatives as telomerase inhibitors through regulation dyskerin were designed and synthesised. The anticancer activity assay in vitro showed that compound 5i 3-(4-(4-isonicotinoylpiperazin-1-yl)butoxy)-5,7 ...
Jie Quan Wang, Meng Di Yang, Xing Chen, Yang Wang, Liu Zeng Chen, Xiu Cheng, Xin Hua Liu   +6 more
doaj   +1 more source

National post-market surveillance assessment of veterinary medicines in Korea during the past decade

BMC Veterinary Research, 2017
Background Veterinary medicines have been widely used for the prevention and treatment of diseases, growth promotion, and to promote feeding efficacy in livestock. As the veterinary medicine industry has steadily grown, it is crucial to set up a baseline
JeongWoo Kang, Hae-chul Park, Yang ho Jang, Md Akil Hossain, Kyunghun Jeong, Mi young Jeong, Seon-Jong Yun, Sung-won Park, Dae gyun Kim, Kwang-jick Lee   +9 more
doaj   +1 more source

The Use of Antihypertensive and Antiplatelet Drugs on Hospital Stroke Patients [PDF]

, 2016
Medicine is one of the most important part of the healing process, the restoration of health and prevention of disease. This study aims to describe the use of drugs, particularly antihypertensive and antiplatelet drugs in stroke patients hospitalized in ...
Abdullah, A. (Akrom), Budiyono, B. (Budiyono), Putri, A. R. (Anggy)   +2 more
core  

Development and Validation of Analytical Procedure for Elemental Impurities in Rosuvastatin Calcium Tablets by ICP-MS and Microwave Digestion

Journal of Analytical Methods in Chemistry
Rosuvastatin calcium is a widely used 3-hydroxy-3-methylglutaryl coenzyme A-reductase inhibitor developed for the treatment of dyslipidemia. To establish a control strategy for the elemental impurities, a new digestion method combined with an inductively
Yajie Hao, Guang Yin, Xuemei Wang, Juan Fu, Qihui Cao, Qinyong Sun, Guimin Zhang, Zhong Feng   +7 more
doaj   +1 more source

Challenges and Opportunities to Updating Prescribing Information for Longstanding Oncology Drugs. [PDF]

, 2019
A number of important drugs used to treat cancer-many of which serve as the backbone of modern chemotherapy regimens-have outdated prescribing information in their drug labeling.
Balogh, Erin P, Bindman, Andrew B, Eckhardt, S Gail, Halabi, Susan, Harvey, R Donald, Jaiyesimi, Ishmael, Miksad, Rebecca, Moses, Harold L, Nass, Sharyl J, Schilsky, Richard L, Sun, Steven, Torrente, Josephine M, Warren, Katherine E   +12 more
core   +2 more sources

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Structural Characterization and Anticoagulant Potential of Colochirus quadrangularis Fucosylated Glycosaminoglycan 5−12 Oligomers with Unusual Branches

Marine Drugs
The depolymerized products and oligosaccharide fractions from sea cucumber fucosylated glycosaminoglycans (FGs) are promising anticoagulant candidates, and more novel FG-derived oligosaccharides from low-priced sea cucumbers are expected to be obtained ...
Xuedong Zhang, Guangwei Yan, Xinming Liu, Jiewen Fu, Xiang Shi, Pei Cao, Yuqian Sun, Shengping Zhong, Jiale Nong, Peiqi Jiang, Yonghong Liu, Baoshun Zhang, Qingxia Yuan, Longyan Zhao   +13 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Effect of RNA Demethylase FTO Overexpression on Biomass and Bioactive Substances in Diatom Phaeodactylum tricornutum

Biology
Phaeodactylum tricornutum is rich in bioactive substances, rendering it valuable in nutrition and medicine. Epigenetic editing mediated by human RNA demethylase FTO can significantly increase the yields of rice and potato and offers significant potential
Yanan Yang, Min Yang, Yihang Zhou, Xiaoqian Chen, Bingyao Huang   +4 more
doaj   +1 more source

New and developing non-adrenoreceptor small molecule drugs for the treatment of asthma [PDF]

, 2017
Introduction: Inhaled corticosteroids (ICS) alone or in combination with an inhaled long-acting beta2-agonist (LABA) are the preferred long-term treatment for adults and adolescents with symptomatic asthma.
Thomson, Neil C.
core   +1 more source