Results 101 to 110 of about 3,598,260 (304)

To Drug or Not to Drug: The Geriatrician Dilemma of Polypharmacy [PDF]

The Journal of nutrition, health and aging, 2020
Aprahamian, I., Morley, John E.
openaire   +4 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Reports of side effects associated with the use of drugs 1968-1975

, 1976
The National Drugs Advisory Board received 716 reports from medical and dental practitioners during 1975. From these 1180 side-effects were recorded associated with the use of drugs during the year.
National Drugs Advisory Board (NDAB)
core  

Antifouling Lipids from Marine Fungi of the Beibu Gulf

Metabolites
Background: The search for environmentally friendly antifouling agents has led to an increased focus on marine natural products. Methods: This study investigated the antifouling potential of lipid fractions extracted from ten marine fungal strains ...
Mengfan Qi, Wang Jiang, Huaqing Huang, Lu Lu, Zhiwei Su, Xiaowei Luo, Chenghai Gao, Yonghong Liu, Xinya Xu   +8 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Drugs for cardiac arrhythmmias, antithrombotic drugs and lipid modulating drugs [PDF]

, 2012
13.1 Drugs for cardiac arrhythmias\ud 13.1.1 Introduction to cardiac arrhythmias\ud 13.1.2 Cardiac action potentials\ud 13.1.3 Mechanisms of cardiac arrhythmias\ud 13.1.3 Class I\ud 13.1.4 Class II\ud 13.1.5 Class III\ud 12.1.6 Class IV\ud 13.1.7 ...
Doggrell, Sheila
core  

A Novel Iodine–Dextrin Complex Exhibits No Acute or Subacute Toxicity and Enhances Azithromycin Efficacy in an LPS-Induced Sepsis Model

Pharmaceutics
Background/Objectives: Our work was designed to study the physicochemical properties, safety profile, pharmacokinetics, and prophylactic efficacy of an original iodine–dextrin-based pharmaceutical formulation (PA), both alone and in combination with ...
Nailya Ibragimova, Arailym Aitynova, Seitzhan Turganbay, Marina Lyu, Alexander Ilin, Karina Vassilyeva, Diana Issayeva, Tamari Gapurkhaeva, Arkadiy Krasnoshtanov, Galina Ponomareva, Amir Azembayev   +10 more
doaj   +1 more source

Therapeutic drug monitoring – antiepileptic drugs [PDF]

British Journal of Clinical Pharmacology, 1998
Aims  To provide a brief critical review of the basis and contemporary practice of monitoring the concentrations of antiepileptic drugs in biological fluids. Methods  The review is based on literature data and observations from clinical practice.
openaire   +10 more sources

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source