Results 101 to 110 of about 3,546,242 (318)

Drug prescription clusters in the UK Biobank: An assessment of drug-drug interactions and patient outcomes in a large patient cohort [PDF]

, 2022
Kyriakos Schwarz, Daniel Trejo Baños, Giulia Rathmes, Michael Krauthammer   +3 more
openalex   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Effect of Drugs on the Secretion from the Tracheal Mucous Membrane [PDF]

, 1896
James F. Calvert
openalex   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

An improved monkey model of myocardial ischemic infarction for cardiovascular drug development [PDF]

, 2022
Keke Wang, Pengfei Han, Lu Huang, Ying Xiao, Jianglong Hou, Pingliang Yang, Yuping Xie, Jindan Cai, Hongge Wang, Y. James Kang   +9 more
openalex   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Comprehensive Analysis of Hub Genes, Biological Mechanism and Predicted Drugs Related to Iron Metabolism in β-Thalassemia [PDF]

, 2023
Rongrong Liu, Yongyu Chen
openalex   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Delta-8-THC acetate-a prodrug of delta-8-THC?: A case report

Forensic Science International: Reports
This case report describes the concurrent analysis of a seized plant material and a urine sample. The seized plant material was found to contain delta-8-THC acetate, a prodrug of delta-8-THC, as a major component.
Jonathan Wong, Evelyn Mei Ling Goh, Jia Ying Goh, Mei Ching Ong, Hooi Yan Moy, Angeline Tiong Whei Yap   +5 more
doaj   +1 more source