Results 31 to 40 of about 1,569,842 (258)

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Transcriptomic Profiling of Oxidative Stress-Associated Immune and Apoptotic Signatures and In Silico Prediction of Therapeutic Candidates for Sjögren’s Syndrome Dry Eye

Biomedicines
Background/Objectives: Sjögren’s syndrome (SS) is a systemic autoimmune disease characterized by lacrimal and salivary gland dysfunction, leading to dry eye and dry mouth.
Jiao Wang, Qiping Qing, Jing Zhang, Siyuan Shi, Xue Yang, Xiaoyu Cai, Zihuan Wang, Weiqian Jiang, Qi Zhang   +8 more
doaj   +1 more source

A study on prevalence of dry eye among postmenopausal women attending ophthalmology OPD [PDF]

Al Ameen Journal of Medical Sciences, 2023
Purpose: Having insufficient lubrication and moisture on the surface of the eye causes dry eye syndrome. Burning, itchy, weary, red, gritty, and dry eyes are all signs of dry eye syndrome. There are other symptoms such as blurred vision and fatigued eyes.
Zoha Arnib, Anand G. Gannur, Z.A. Golewale, Madhu A. Gannur, Vybhavi P. Kaushik   +4 more
doaj  

Vitamin D in dry eye and myopia [PDF]

, 2017
Vitamin D is important to human health with a variety of systemic diseases linked to vitamin D deficiency. The effect of a two month treatment of a vitamin D oral supplement on the ocular surface in older people with dry eye and on binocular vision in ...
Yang, Chih Huang
core   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

From patient to advisor: establishing a patient council for dry eye research

Research Involvement and Engagement
Objective To assess the feasibility and participant-reported perceptions of a multiphase training program that jointly prepares patients and researchers for collaboration in dry eye patient-centered research.
Natalia A. Warren, James Robert Adams
doaj   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Age Is a Determining Factor of Dry Eye-Related Signs and Symptoms

Diagnostics, 2020
Purpose: The reported signs and symptoms of dry eye (DE) have been discordant. This study evaluated risk factors of DE-related symptoms and signs to explore their association with patient demographics, focusing on the age factor.
Masahiko Ayaki, Kazuno Negishi, Motoko Kawashima, Miki Uchino, Minako Kaido, Kazuo Tsubota   +5 more
doaj   +1 more source

Comparison of the Ocular Microbiomes of Dry Eye Patients With and Without Autoimmune Disease

Frontiers in Cellular and Infection Microbiology, 2021
PurposeThe pathogenesis of dry eye concomitant with autoimmune disease is different from that of dry eye without autoimmune disease. The aim of this study was to explore differences in the microbiota diversity and composition in dry eye with and without ...
Yun Qi, Yong Wan, Tianhui Li, Ming Zhang, Yu Song, Yaguang Hu, Yining Sun, Li Li   +7 more
doaj   +1 more source

The Gut–Heart Axis in Systemic Sclerosis: Evidence From a Large Prospective Early Disease Cohort

Arthritis Care &Research, EarlyView.
Objective Cardiac involvement significantly impacts prognosis in systemic sclerosis (SSc), highlighting the need for early risk stratification. Gastrointestinal (GI) symptoms are common and often manifest early. Emerging data suggest a link between GI and cardiac manifestations, possibly through shared mechanisms like dysautonomia.
Francesca R. Di Ciommo, Ashish P. Balar, Aidan K. Strother, Subhash Kulkarni, Michael Hughes, Brian Skaug, Maureen D. Mayes, Shervin Assassi, Ali Y. Ayla, Zsuzsanna H. McMahan   +9 more
wiley   +1 more source