Results 71 to 80 of about 373,290 (326)

Novel Bioconjugate Materials: Synthesis, Characterization and Medical Applications

Advanced Healthcare Materials, EarlyView.
This review discusses the bioconjugation of novel materials grouped under “biological”, “hybrid” and “synthetic” categories. Medical applications ranging from cancer therapy and diagnostics to optogenetics and tissue engineering are explored, and conjugation trends are highlighted as a general guide. The review concludes with a comparison of techniques
Ellie Martin, Sean P. Doidge, Eiman Aleem, Suela Kellici, Steven Dunn, Claire Atkinson, Philip D. Howes   +6 more
wiley   +1 more source

Fluorescence-based reagent and spectrum-based optical reader for lactoferrin detection in tears: differentiating Sjögren’s syndrome from non-Sjögren’s dry eye syndrome

Scientific Reports
Identification of an early biomarker and effective testing device to differentiate dry eye disease secondary to autoimmune disease (Sjögren’s syndrome dry eye disease) from non-Sjögren’s dry eye disease are prerequisites for appropriate treatment.
Chia-Ying Tsai, Chitsung Hong, Min-Yen Hsu, Tso-Ting Lai, Ching-Wen Huang, Cheng-Yo Lu, Wei-Li Chen, Chao-Min Cheng   +7 more
doaj   +1 more source

Ocular mucins in dry eye disease

Experimental Eye Research, 2019
Dry eye disease is a common and multifactorial disease with a high prevalence worldwide. Water loss, reduced expression of glycocalyx mucins, and loss of goblet cells secreting gel-forming mucins are hallmarks of dry eye disease. Mucins are large and complex heavily glycosylated proteins.
Portal, Céline, Gouyer, Valérie, Gottrand, Frédéric, Desseyn, Jean-Luc   +3 more
openaire   +6 more sources

Pulmonary Delivery of siRNA Anti‐TNFα‐loaded Lipid Nanoparticles for Rapid Recovery in Murine Acute Lung Injury

Advanced Healthcare Materials, EarlyView.
In a murine model of acute lung injury, pulmonary administration of lipid nanoparticles carrying TNFα siRNA enables targeted delivery to immune cells. The study emphasises the importance of optimizing LNP distribution and delivery timing to improve therapeutic outcomes and develop emergency therapies for lung hyperinflammation.
Qinglin Wang, Jihana Achour, Laila Emam, Younes Louaguenouni, Catherine Cailleau, Françoise Mercier‐Nomé, Séverine Domenichini, Claudine Delomenie, Sezen Gul, Juliette Vergnaud, Nicolas Tsapis, Arnaud Mansart, Djillali Annane, Francois Fay, Elias Fattal   +14 more
wiley   +1 more source

Etiology, prevalence, and treatment of dry eye disease

Clinical Ophthalmology, 2009
Johnny L GaytonEyesight Associates, Warner Robins, GA, USAPurpose: This review article examines the prevalence, etiology, and current therapies of dry eye disease, with special focus on postmenopausal women.Method: A systematic literature search ...
Johnny L Gayton
doaj  

Pro-Secretory Activity and Pharmacology in Rabbits of an Aminophenyl-1,3,5-Triazine CFTR Activator for Dry Eye Disorders. [PDF]

, 2017
PurposePharmacological activation of ocular surface cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels is a potential pro-secretory approach to treat dry eye disorders.
Felix, Christian M, Lee, Sujin, Levin, Marc H, Verkman, Alan S   +3 more
core   +2 more sources

Myeloperoxidase Luminol Reaction – A Novel Faecal Assay for Predicting Colonoscopy Findings in Patients with Ulcerative Colitis: A Pilot Cross‐Sectional Clinical Study

Advanced Healthcare Materials, EarlyView.
Can luminol detect faecal inflammation? This study explores the development and optimisation of a rapid novel assay ‐ Myeloperoxidase Luminol Reaction (MPOLR) for the detection of faecal myeloperoxidase activity. This simple and rapid luminol‐based approach competes with clinically validated faecal biomarkers in predicting endoscopic findings in ...
Viraj Kariyawasam, Taylor Davis, Mark Ghali, David Tejcek, Thomas R O'Neil, Ella Verley, Matthew Griffiths, Miguel Campos, Ingrid Bonney, Andrew C. Bulmer, Yogambha Ramaswamy, Nikola Mitrev, Crispin Corte, Paul K. Witting, Belal Chami   +14 more
wiley   +1 more source

Diagnosis of dry eye disease and emerging technologies

Clinical Ophthalmology, 2014
Maya Salomon-Ben Zeev,1 Darby Douglas Miller,2,3 Robert Latkany1,21The Dry Eye Center at Physician Eyecare of New York, 2New York Eye and Ear Infirmary, 3Laser and Corneal Surgery Associates, New York, NY, USAAbstract: Dry eye is one of the most commonly
Zeev MSB, Miller DD, Latkany R
doaj  

A Patient‐Specific 3D Printed Carotid Artery Model Integrating Vascular Structure, Flow, and Endothelium Responses

Advanced Healthcare Materials, EarlyView.
This study introduces the first miniaturized, patient‐specific carotid artery model created via 3D printing using GelMA with embedded vascular cells. Combining CFD, PIV, and flow perfusion, the model replicates anatomically dependent hemodynamics and cellular responses.
Jorge A. Catano, Louis Jun Ye Ong, Mingyang Yuan, Yunkun Qu, Jessica Benitez, Prasad KDV Yarlagadda, Yi‐Chin Toh, Zhiyong Li   +7 more
wiley   +1 more source

Therapeutic approaches with intravitreal injections in geographic atrophy secondary to age-related macular degeneration: current drugs and potential molecules [PDF]

, 2019
The present review focuses on recent clinical trials that analyze the efficacy of intravitreal therapeutic agents for the treatment of dry age-related macular degeneration (AMD), such as neuroprotective drugs, and complement inhibitors, also called ...
Cerini, Alberto, Greco A., La Cava M, Lambiase A, Limoli PG, Nebbioso M   +5 more
core   +1 more source