Results 61 to 70 of about 81,824 (302)
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Comparison of the Paddy Drying Process and Milling Quality between Re-circulating and Conventional Batch Type Dryers [PDF]
Journal of Agricultural Machinery, 2019 Introduction High energy consumption and non-uniformity drying in conventional batch type dryer are the common problems in paddy dying industry. Non-uniformity drying causes to kernel breaking chance in the milling process.
H. R Gazor, A Moumeni
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
DEVELOPMENT OF A NOVEL ENERGY EFFICIENT ADSORPTION DRYER WITH ZEOLITE FOR HEAT SENSITIVE PRODUCTS
, 2010 Drying is a basic operation in wood, food, pharmaceutical and chemical industry. The operation is important to enhance the preservation properties of agriculture crops and pharmaceutical products, to reduce the costs for transportation, to increase ...
Djaeni, M
core +1 more source
International Journal of Renewable Energy Development, 2018 Pineapple (Ananascomosus) slices were dried with the aid of a heat pump assisted dryer (HPD). During this process, air velocity was kept constant at 1m/s, while air temperatures were changed as 37°C, 40°C and 43°C.
Cüneyt Tunçkal +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Gray Whale (Eschrichtius robustus) Health and Disease: Review and Future Directions
Frontiers in Marine Science, 2020 The eastern North Pacific gray whale (Eschrichtius robustus) population is considered “recovered” since the days of commercial whaling, with a population of over 25,000 animals.
Raphaela Stimmelmayr +2 more
doaj +1 more source
Experimental silo-dryer-aerator for the storage of soybean grains
, 2018 This study aimed to verify the capacity of silo-dryer-aerator prototype equipment operating as a silo-storage-aerator for soybean quality analysis. Soybeans with water content of 17% (wet basis – w.b.) were dried and stored in a silo-dryer-aerator system
Ângelo F. C. Lemes +5 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source