Results 71 to 80 of about 653,244 (303)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Study on the Contact Parameter Calibration of the Maize Kernel Polyhedral Discrete Element Model

Agriculture
During maize production and transportation, maize kernels frequently interact with mechanical components. To accurately simulate the interaction process between maize and mechanical components, it is essential to establish a reliable maize kernel model ...
Huhu Chen, Haipeng Lin, Xuefeng Song, Fengwei Zhang, Fei Dai, Ting Yang, Baicheng Li   +6 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Drying of Heat Sensitive Materials of High Moisture Content in Mechanically Spouted Bed of Inert Particles [PDF]

, 2008
In drying operation the material characteristics such as heat sensitivity, moisture content and particle size are of great importance, which should be taken into account in selection of proper design and conditions for the process.
Gyenis, János, Pallai-Varsányi, E., Tóth, J.   +2 more
core   +1 more source

Modeling and simulation of drying operation in PVC powder production line: a pneumatic dryer model [PDF]

, 2012
A one-dimensional steady-state model is developed to simulate drying of PVC powder in a pneumatic dryer. In this model, a two-phase continuum model was used to describe the steady-state flow of a dilute dispersed phase (wet PVC powder) and a continuous ...
Ansart, Renaud, Hemati, Mehrdji, Aubin, Antoine, Lasuye, Thierry, Branly, Marc   +4 more
core  

Kiln drying behavior utilizing drying rate of lumber from six fast-growth plantation species in Costa Rica [PDF]

, 2016
Artículo científicoThe objective was to study the effect of the drying time and moisture content variations on the drying rate during kiln drying. The moisture content is a good predictor of the variation in drying rate; to determine the drying rate, the
Moya-Roque, Róger, Cynthia Salas, Tenorio-Monge, Carolina, Carolina Tenorio, Róger Moya, Salas-Garita, Cynthia   +5 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Water Vapor Emission From Rigid Mesoporous Materials during the Constant Drying Rate Period

, 2012
It has long been thought that the evaporation rate from mesoporous materials during the constant drying rate period (CDRP) is equal to that of a free-water surface, due to the presence of a liquid film covering the surface of the material.
Gonçalves, T. D., Brito, V., Pel, L.
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Improvement of Energy Efficiency of Dehydration Processes in the Conditions of Selective Supply of Electromagnetic Energy [PDF]

Problems of the Regional Energetics
An analysis of conventional dehydration processes used in food technologies—evaporation and drying—has been conducted, and their key challenges have been identified. The global research experience in dehydration technologies based on innovative microwave
Burdo O.G., Levitsky A.P., Sirotyuk I.V., Burdo A.K., Kepin N.I., Petrovsky V.V., Yevtushenko I.N.   +6 more
doaj   +1 more source