Results 81 to 90 of about 653,244 (303)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Production of MgAl/layered double hydroxide microspheres and investigation of the volumetric heat transfer coefficient in spray drying

open access: yesHeliyon
Layered Double Hydroxides (LDH) are synthetic materials nanostructured in two dimensions that present positively charged layers with interspersed anions for charge and structure balancing. Being recognized as a promising material for various applications,
Luiz D. Silva Neto   +2 more
doaj   +1 more source

FINANCIAL ANALYSIS OF ON-FARM GRAIN DRYING [PDF]

open access: yes
Artificial drying of corn in the Southeastern Coastal Plain was shown to be financially feasible for average annual per farm production levels of greater than 10,000 bushels.
Lieblich, Mark S., Kiker, Clyde F.
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Approximate model of wet particle drying

open access: yesСельскохозяйственные машины и технологии, 2017
When plant refuse burning process of drying of fuel is transferred to the furnace camera. Drying of large particles of fuel from the very beginning proceeds in the period of the drooping combustion rate.
A. V. Golubkovich, A. N. Dadyko
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

STUDY OF GRAIN DRYING IN THE AUTOMATED GRAIN DRYING UNIT

open access: yesСельскохозяйственные машины и технологии, 2018
Mine and column grain dryers are a fairly complex object of control in the production line. The process of grain drying is characterized  by a large number of parameters, quantitatively and qualitatively characterizing the dryer operation.
S. A. Pavlov, T. F. Frolova
doaj   +1 more source

Optimized wood drying

open access: yes, 2000
Nonlinear programming methods are used to create effective drying schedules for boards. A two-dimensional. orthotropic drying model is connected to an optimization routine that solves convex sub-problems. The iterative optimi7ation program calculates the
Arfvidsson, J, Carlsson, Peter,
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Performance Determination of New Universal Dryer Models

open access: yesСельскохозяйственные машины и технологии, 2018
Drying of seed material plays an important part in the system of post-harvest processing and greatly affects the yield quality of the seed material. (Research purpose) Determination of the performance of two modules of a new dryer, taking into account ...
A. S. Klyuchnikov
doaj   +1 more source

Home - About - Disclaimer - Privacy