Results 81 to 90 of about 638,772 (310)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Emic and Ethic Knowledge of Bamboo’s Characteristic in Process of Making Angklung [PDF]

, 2015
Bamboo as raw material of angklung has not received special attention yet, whereas the quality of angklung will be highly influenced by the quality of bamboo as its main material.
Amalia, Annisa, Cundaningsih, Nurvita, Husodo, Teguh, Irawan, Budi, Saputri, Syaima Rima   +4 more
core  

CDIO project on MaViCo heat compress for tackwondo players [PDF]

, 2020
Taekwondo is a traditional Korean martial arts sport which is currently practiced by many countries around the world. As claimed by the International Olympics Committee (2015), this sport made its debut in 1988 as a demonstration of Olympic sport in ...
Abdullah Ahmed Ba Odhah, Ali, Abdulrahman Abdulaziz Al-Awadhi, Khaled, Bah, Aaisha Negeh, Mohamed Nasser,, Muhammad Iman Ikhwan   +3 more
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Effects of different drying techniques on sea buckthorn pomace: comprehensive assessment of drying characteristics, physicochemical properties, and odor

Frontiers in Sustainable Food Systems
This study investigated the effects of hot air drying (HAD), infrared-assisted hot air drying (IR-HAD), vacuum freeze drying (VFD), and pulsed-vacuum drying (PVD) on the drying characteristics, color, microstructure, total phenolic content (TPC), total ...
Xiang Zhou, Xiaoqiang Zhang, Xinyu Liu, Xinyu Ji, Qian Zhang, Qian Zhang, Qian Zhang, Xuhai Yang, Xuhai Yang, Xuhai Yang   +9 more
doaj   +1 more source

Thin Layer Drying Characteristic of Morinda Citrifolia Fruit and Drying Effects on 6 – Methoxy-7-Hydoxy-Coumarin Content [PDF]

, 2004
This study presents the thin layer drying characteristic of Morinda Citrifolia Linn fruit and drying effects on scopoletin content. The optimum mature stage of M.citrifolia fruit was found to be four months after bud flowering with high scopoletin ...
Sulaiman, Rabiha
core  

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Karakteristik Pengeringan Bawang Merah (Alium Ascalonicum. L) Menggunakan Alat Pengering ERK (Greenhouse) [PDF]

, 2017
Aim of this research was to determine drying rate and moisture content changes on Greenhouse (ERK) Dryer. Result was showed using graphic by analyzing drying rate characteristics of Greenhouse Dryer.
Islami, A. (Amalia), Murad, M. (Murad), Priyati, A. (Asih)   +2 more
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source