Results 81 to 90 of about 12,118,806 (251)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Comparison of the retention of 6-gingerol in drying of ginger under modified atmospher heat pump drying and other drying methods

, 2006
A heat pump dryer using normal air, nitrogen, and carbon dioxide was selected to dry sliced West Indian ginger (Zingiber officinale Roscoe) rhizome (3 mm in thickness).
Perera, Conrad, Tian, M, Perera, C.O., Hawlader, M.N.A., Tian, M., Hawlader, MNA   +5 more
core   +1 more source

Effects of drying methods and temperatures on protein, pasting, and thermal properties of white floury corn

, 2020
The objective of this study was to investigate the effects of drying methods (tempering–10 min, tempering–30 min, fixed-bed, and infrared radiation) and drying air temperature (70 °C and 90 °C) on proteins, thermal, and pasting properties of white floury
Da Silva Timm, N., Oliveira, M., Ferreira, C. D., Lang, G. H., Ramos, A. H.   +4 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Comparison and Evaluation of Various Drying Methods on Surface Hardness of Type IV Dental Stones: An In vitro Study

Journal of Pharmacy and Bioallied Sciences
Accurate dental restorations require die materials with optimal surface hardness. This study evaluated drying method effects on three Type IV dental stones: Elite Rock (ZERMACK), Fuji Rock (GC), and Kal Rock (KALROCK).
D Sriteja, VS Lakshmi Thorreti, SV Ravindra, M Rohit, Sriharsha Pudi, Abnuri Karan Kumar   +5 more
doaj   +1 more source

Analysis of two drying methods on the yield and activity of sulfated polysaccharides extracted from Halymenia sp. (Rhodophyceae)=Análise de dois métodos de secagem sobre o rendimento e atividade de polissacarídeos sulfatados extraídos da rodofícea Halymenia sp. [PDF]

Acta Scientiarum: Biological Sciences, 2012
Sulfated polysaccharides (SPs) have attracted growing interest for various biotechnological applications. We evaluated the efficiency of two methods of drying SPs (M I and II) extracted from Halymenia sp Rhodophyceae in order to compare the yield ...
Norma Maria Barros Benevides, Érika Façanha Bessa, Ismael Nilo Lino de Queiroz, Ana Luíza Gomes Quinderé, José Ariévilo Gurgel Rodrigues, Edfranck de Sousa Oliveira Vanderlei   +5 more
doaj  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Drying of Curcuma (Curcuma xanthorrhiza roxb) Using Double Plate Collector Solar Dryer [PDF]

, 2012
Curcuma (Curcuma xanthorrhiza roxb) currently used as traditional medicine and as a dye. If the Curcuma will be saved then the water content should not be more than 10-11%.
Tjukup , Marnoto, Wasir , Nuri, Bayu , Ardinanto, M, Mahreni, Ratna E. , Puspitasari   +4 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Determination of Various Drying Methods’ Impact on Odour Quality of True Lavender (Lavandula angustifolia Mill.) Flowers

Molecules, 2019
True lavender flowers (Lavandula angustifolia Mill.) is a critical source of essential oils and a flavouring agent used in numerous industries like foods, cosmetics and pharmaceuticals.
Jacek Łyczko, Klaudiusz Jałoszyński, Mariusz Surma, José Miguel García-Garví, Ángel A. Carbonell-Barrachina, Antoni Szumny   +5 more
doaj   +1 more source