Results 191 to 200 of about 9,342 (257)

Enhancing Meat Quality Through Dietary Fiber: Insights Into the Gut Microbiota‐Derived Short‐Chain Fatty Acids‐Muscle Axis

open access: yesAnimal Research and One Health, EarlyView.
Dietary fiber (DF) modulates meat quality through the gut‐muscle axis by reshaping gut microbiota, improving intestinal integrity, reducing inflammation, and regulating muscle metabolism. These mechanisms influence muscle fiber characteristics and post‐mortem biochemistry, thereby enhancing tenderness, juiciness, color, flavor, and nutritional value of
Zeshan Zulfiqar   +8 more
wiley   +1 more source

Leveraging Big Multitemporal Multisource Satellite Data and Artificial Intelligence for the Detection of Complex and Invisible Features: The Case of Extensive Irrigation Mapping

open access: yesArchaeological Prospection, EarlyView.
ABSTRACT The detection of buried or obscured archaeological features remains a central challenge in landscape archaeology, particularly in the irrigated floodplains of Mesopotamia where levees and canals formed the basis of complex agrarian systems. This study presents a deep learning–based approach for the large‐scale, automated detection of ancient ...
Nazarij Buławka   +4 more
wiley   +1 more source

Integrating Remote Sensing, Archaeological Survey and Geophysical Prospections for the Enhancement of Roman Doclea, Montenegro

open access: yesArchaeological Prospection, EarlyView.
ABSTRACT The Roman city of Doclea is a key archaeological site of Montenegro, valued for its impressive remains and its role in the nation's cultural identity within European and the Mediterranean history. Doclea was the second‐largest city in the province of Roman Dalmatia, a municipium created in the first century ad and named after the Illyrian ...
Tatjana Koprivica   +5 more
wiley   +1 more source

Beyond the label: Rethinking off‐label drug use in paediatrics. Towards a scientifically grounded and safer future for paediatric pharmacotherapy

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden   +3 more
wiley   +1 more source

Pharmacokinetic profiling of imatinib in relation to CYP3A4 activity in leukaemia patients

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aim Imatinib pharmacokinetics exhibit large interindividual variability because of differences in CYP3A4 activity—the main imatinib‐metabolizing enzyme. While therapeutic drug monitoring is effective, it requires steady‐state conditions and frequent sampling.
Anna Sofie Buhl Rasmussen   +14 more
wiley   +1 more source

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