Results 111 to 120 of about 48,188 (262)

Diffusion MRI reveals amyloid plaque–associated cellular signatures through spatial transcriptomic integration [PDF]

Alzheimers Dement
Abstract INTRODUCTION Amyloid plaque deposition is a defining feature of Alzheimer's disease (AD), yet how plaque‐associated cellular alterations are reflected in noninvasive imaging remains unclear. METHODS We integrated high‐resolution diffusion magnetic resonance imaging (dMRI) with spatial transcriptomics (ST) in an AD mouse model.
Han X, Hu R, Ping X, Chen J, Liu J, Liu Z, Jin X, Gao X, Lin M, Zhao Y, Wang N.   +10 more
europepmc   +2 more sources

Immune proteomic associations with indices of cortical development in 5‐year‐old children

Journal of Anatomy, EarlyView.
Typically developing 5‐year‐old children (n = 101–126) from the FinnBrain Birth Cohort Study, Finland, underwent both targeted serum immune proteomics and magnetic resonance brain imaging. Multiple inflammatory markers, from one cluster of co‐expressed immune proteins, were negatively associated with indices of cortical development, including thickness,
Aaron Barron, Aylin Rosberg, Jetro J. Tuulari, Minna Lukkarinen, Harri Merisaari, Eero Silver, Venla Kumpulainen, Anni Copeland, Ekaterina Saukko, Alex M. Dickens, Matej Oresic, Tuulia Hyötylainen, Linnea Karlsson, Hasse Karlsson, Isabella L. C. Mariani Wigley, Elmo P. Pulli   +15 more
wiley   +1 more source

Multiscale cross modal fusion and cascaded signal propagation for drug target interaction prediction. [PDF]

iScience
Wang B, Xie X, Zou H, Peng S.
europepmc   +1 more source

Decrease of excessive daytime sleepiness after shunt treatment for normal pressure hydrocephalus

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Sleepiness and apathy are often reported in patients with normal pressure hydrocephalus. However, research on outcomes after shunt surgery has mainly focused on the classical triad symptoms, that is, gait, cognition, and bladder dysfunction. This study aimed to describe the effects of shunt treatment on excessive daytime sleepiness and whether ...
Simon Lidén, Anna Lindam, Dan Farahmand, Anne‐Marie Landtblom, Katarina Laurell   +4 more
wiley   +1 more source

Nonparametric Survival Estimation With Contaminated and Adjudicated Events

Scandinavian Journal of Statistics, EarlyView.
ABSTRACT We study the conditional expert Kaplan–Meier estimator, an extension of the classical Kaplan–Meier estimator designed for time‐to‐event data subject to both right‐censoring and contamination. Such contamination, where observed events may not reflect true outcomes, is common in applied settings, including insurance and credit risk, where expert
Martin Bladt, Kristian Vilhelm Dinesen
wiley   +1 more source

Brain perivascular diffusion and cognitive impairment in heart failure with preserved ejection fraction. [PDF]

Front Med (Lausanne)
Yu T, Duan C, Sun M, Liu Y, Yuan Y.
europepmc   +1 more source

Characterization of postnatal brain injury and behavioural deficits in a rat model of placental insufficiency‐induced fetal growth restriction

The Journal of Physiology, EarlyView.
Abstract figure legend Fetal growth restriction (FGR) is a common pregnancy complication associated with long‐term neurodevelopmental impairments. Using the reduced uterine perfusion pressure (RUPP) rat model of placental insufficiency‐induced FGR, this study demonstrates that FGR leads to persistent anatomical, histological and behavioural ...
Judit Alhama‐Riba, Caroline G. M. de Theije, Valentina Salvi, Dominique Viveen, Sebastiaan W. T. Corstjens, Marijke. E. J. Achterberg, Yohan van de Looij, Freek E. Hoebeek, Cora H. A. Nijboer   +8 more
wiley   +1 more source

Disease-specific patterns of glymphatic-related dysfunction between multiple sclerosis and neuromyelitis optica spectrum disorder. [PDF]

Front Immunol
Chen X, Zhang K, Dong X, Zhang X, Shi Z, Yan Z, Zhu Q, Peng Y, Han Y, Li Y.   +9 more
europepmc   +1 more source

Comparative Performance Analysis of an Open Source Motion‐Compensated Cardiac Diffusion Sequence Across Different MRI Systems and Gradient Strengths—A Pilot Study

Magnetic Resonance in Medicine, Volume 96, Issue 6, Page 2629-2641, December 2026.
ABSTRACT Purpose To validate the performance of an open‐source cardiac diffusion sequence framework and to investigate hardware‐based performance differences. Methods Three second order motion compensated sequence files were compiled using Pulseq and applied across different MRI systems to image five volunteers.
Eric Arbes, Ariel Hannum, Johannes Fischer, Qingping Chen, Sebastian Littin, Alexander Maier, Michael Bock, Simon Reiss   +7 more
wiley   +1 more source

Diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Parkinson's disease patients with subjective cognitive decline. [PDF]

Front Aging Neurosci
Wei S, Qiu M, Gong M, Zou W, Ren J, Qiu W.   +5 more
europepmc   +1 more source