Results 131 to 140 of about 46,270 (256)

Targeting progressive multiple sclerosis: Toward mechanism‐informed precision medicine

Journal of Internal Medicine, Volume 300, Issue 3, Page 238-257, September 2026.
Abstract Multiple sclerosis has undergone a therapeutic revolution over the past three decades. Randomized clinical trials and real‐world data demonstrate that modern disease‐modifying therapies substantially reduce relapse rates and acute inflammatory activity detected by magnetic resonance imaging (MRI).
Fredrik Piehl, Gonçalo Castelo‐Branco, Maja Jagodic, Tomas Olsson   +3 more
wiley   +1 more source

Glymphatic-related imaging findings in type 2 diabetes mellitus: a systematic review and exploratory meta-analysis of DTI-ALPS studies. [PDF]

Front Aging Neurosci
Chen Y, Zhang J, Zheng X, Zhou Y, Hou X.
europepmc   +1 more source

Evaluation of dosimetric impact and plan robustness of MLC motion and setup errors in SRS for multiple brain metastases

Journal of Applied Clinical Medical Physics, Volume 27, Issue 8, August 2026.
Abstract Background HyperArc is an effective technique for treating multiple small brain metastases using high‐definition, precise radiation. However, the small size of individual lesions makes treatment vulnerable to inherent inaccuracies from beam‐limiting devices such as multi‐leaf collimators (MLCs), as well as patient setup errors.
Huijun Xu, Hong Zhang, Weiguang Yao, Jinghao Zhou, Yannick Poirier, Junliang Xu, Stewart Becker, Guozhen Luo, Mark Mishra, Shifeng Chen, Baoshe Zhang   +10 more
wiley   +1 more source

Glymphatic dysfunction and neuroinflammation in FXTAS: evidence from DTI-ALPS and gene expression analysis. [PDF]

Front Mol Neurosci
Elias-Mas A, Moreno EG, Martí CP, Rubio-Roy M, Aguado-Gracia J, Muñoz-Moreno E, Hinojosa A, Herrero I, Alvarez-Mora MI, Hagerman R, Wang JY, Zaro I, Ortiz SG, Krupinski J, Rodriguez-Revenga L.   +14 more
europepmc   +1 more source

How Advanced Artificial Intelligence Technologies Shape Drug–Drug and Drug–Target Interaction Modeling

Advanced Science, Volume 13, Issue 44, 7 August 2026.
This review explores the convergence of artificial intelligence technologies in modeling drug–drug and drug–target interactions. By evaluating advanced feature engineering, architectural innovations, and learning paradigms reveals shared evolutionary trends and critical challenges, such as cold‐start settings and shortcut learning.
Xin Sun, Tong Wang
wiley   +1 more source

Impact of the diagnosis-to-treatment interval on the survival of patients with CD5-positive diffuse large B-cell lymphoma. [PDF]

Ann Hematol
Nato Y, Miyazaki K, Maruyama D, Takahashi H, Sunami K, Negoro E, Murakami S, Okada T, Takayama N, Miyazawa Y, Choi I, Momose S, Kaneda Y, Yoshida M, Tomita N, Murayama T, Nishikori M, Hiraga J, Toyama K, Takahashi N, Masunari T, Takizawa J, Tawara I, Asano N, Ohshima K, Izutsu K, Kato K, Suzuki R, Yamaguchi M.   +28 more
europepmc   +1 more source

Pathogenic PF4/Polyanion ELISA‐Negative Antibodies in HIT

American Journal of Hematology, Volume 101, Issue 8, Page 1790-1798, August 2026.
ABSTRACT Background Platelet factor 4‐polyanion enzyme‐linked immunosorbent assays (ELISAs) are considered highly sensitive for diagnosing heparin‐induced thrombocytopenia (HIT), such that current practice guidelines recommend use of ELISA‐negative results to exclude HIT.
Adam J. Kanack, Noah P. Splinter, Emily E. Mauch, Leben Tefera, Morayma Reyes Gil, Sakshi Jasra, Andrew Goodwin, Kristi J. Smock, Hadiyah Ahmad, Aneel Ashrani, Nathaniel L. Robinson, Ana I. Casanegra, Curtis G. Jones, Shannon M. Pechauer, Erin Yttre, Richard H. Aster, Mindy C. Kohlhagen, Rachel R. Leger, Gretchen Johns, David L. Murray, Lu Zhou, Demin Wang, Renren Wen, Dong Chen, Rajiv K. Pruthi, Anand Padmanabhan   +25 more
wiley   +1 more source

Glymphatic Dysfunction and Related Brain Structure Changes in Major Depressive Disorder: Effects of Glymphatic Function in Mediating Neuroinflammation. [PDF]

Psychiatry Investig
Shin D, Han KM, Kang Y, Auer DP, Tae WS, Ham BJ.   +5 more
europepmc   +1 more source

Early identification of vascular cognitive impairment from a multimodal perspective: a combined diagnosis from targeted cognitive assessments, imaging biomarkers, and molecular fluid biomarkers to ecological behavioral characteristics

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract Vascular cognitive impairment (VCI), the second leading cause of dementia, is characterized by heterogeneous pathophysiology and a potentially reversible early phase, underscoring the need for timely identification. This review synthesizes advances across four complementary domains – targeted cognitive assessments, imaging biomarkers ...
Wenqi Song, Xiaoqun Liu, Tianrui Yu, Yuanyuan Xiang, Peijie Fu, Moxin Wu, Xiaoping Yin, Xiaorong Zhang, Zhiying Chen   +8 more
wiley   +1 more source

The role of vascular risk factors in white matter tract microstructure: a multi‐cohort study in older adults

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Vascular risk factors (VRFs) contribute to white matter microstructural degeneration, but their tract‐specific contributions are unclear. We assessed the independent associations of four major VRFs with white matter microstructure in a large, multi‐cohort study.
James D. LeFevre, Yukti Vyas, Aditi Sathe, Niranjana Shashikumar, Kimberly R. Pechman, Yisu Yang, Alaina Durant, Praitayini Kanakaraj, Michael E. Kim, Chenyu Gao, Nancy R. Newlin, Karthik Ramadass, Nazirah Mohd Khairi, Zhiyuan Li, Tianyuan Yao, Shannon L. Risacher, Panpan Zhang, Kurt G. Schilling, Annie J. Lee, Adam M. Brickman, Richard Mayeux, Jesse Mez, for the Alzheimer's Disease Neuroimaging Initiative (ADNI), The Alzheimer's Disease Sequencing Project (ADSP)The ADSP Phenotype Harmonization Consortium (ADSP‐PHC), Walter Kukull, Sarah A. Biber, Bennett A. Landman, Barbara B. Bendlin, Sterling C. Johnson, Julie Schneider, Lisa L. Barnes, David A. Bennett, Andrew J. Saykin, Michael L. Cuccaro, Timothy J. Hohman, Angela L. Jefferson, Derek B. Archer   +36 more
wiley   +1 more source