Results 111 to 120 of about 2,778,255 (309)
, 2021 Spa: La problemática de tierras en Colombia es uno de los principales conflictos del medio rural, ya que, ha sido permeada por fenómenos de violencia, expansión de la frontera agrícola, conquista de territorios baldíos y en especial, el proceso de paz.
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Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
DVOJINA U JEZIKU TEKSTOVA HRVATSKOGLAGOLJIČKE NELITURGIJSKE KNJIŽEVNOSTI XV. STOLJEĆA
Rasprave Instituta za Hrvatski Jezik i Jezikoslovlje, 1999 Članak je posvećen opisu i problemima funkcioniranja dvojine kao elementa gramatičke kategorije broja u jeziku Petrisova zbornika (1468), najznačajnijega kodeksa glagoljaške neliturgijske književnosti XV. stoljeća.
Eduard Hercigonja
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Revista Eureka sobre Enseñanza y Divulgación de las CienciasLa energía es un concepto fundamental que permite la explicación y predicción de fenómenos en todos los campos de la física. Esto puede explicar que su comprensión se haya convertido en un objetivo de aprendizaje prioritario en los currículos de ciencias
Nicolás Gandolfo +4 more
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Dual Drug Loaded Lipid Nanocarrier Formulations for Topical Ocular Applications
International Journal of Nanomedicine, 2022 Ahmed Adel Ali Youssef,1,2 Narendar Dudhipala,2 Soumyajit Majumdar2,3 1Department of Pharmaceutical Technology, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, 33516, Egypt; 2Department of Pharmaceutics and Drug Delivery, School of Pharmacy ...
Youssef AAA, Dudhipala N, Majumdar S
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Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
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Graphical Models, 2002 Summary: The dual of a 2-manifold polygonal mesh without boundary is commonly defined as another mesh with the same topology (genus) but different connectivity (vertex--face incidence), in which faces and vertices occupy complementary locations and the position of each dual vertex is computed as the center of mass (barycenter or centroid) of the ...
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source