Results 171 to 180 of about 6,390,692 (375)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Wild-type p53 controls cell motility and invasion by dual regulation of MET expression

, 2011
Chang‐Il Hwang, Andrés Matoso, David C. Corney, Andrea Flesken‐Nikitin, Stefanie Körner, Wei Wang, Carla Boccaccio, Snorri S. Thorgeirsson, Paolo M. Comoglio, Heiko Hermeking, Alexander Yu. Nikitin   +10 more
openalex   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Author's Reply. RE: The effectiveness of telepsychiatry: thematic review

BJPsych Bulletin, 2023
Karrish Devan, Gunjan Sharma
doaj   +1 more source

The Dual Use of SAM Molecules for Efficient and Stable Perovskite Solar Cells [PDF]

Jiajia Suo, Bowen Yang, Dmitry Bogachuk, Gerrit Boschloo, Anders Hagfeldt   +4 more
openalex   +1 more source

Continual learning fault diagnosis: A dual-branch adaptive aggregation residual network for fault diagnosis with machine increments

, 2022
Bojian Chen, Changqing Shen, Juanjuan Shi, Lin Kong, Luyang Tan, Dong Wang, Zhongkui Zhu   +6 more
openalex   +1 more source

Dual variational methods in critical point theory and applications

, 1973
A. Ambrosetti, P. Rabinowitz
semanticscholar   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Progressive outer retinal necrosis: Dual virus involvement

Indian Journal of Ophthalmology, 2020
Bruttendu Moharana, Uday Tekchandani, Surya Prakash Sharma, Aman Kumar, Ramandeep Singh   +4 more
doaj   +1 more source

Capture and detumbling control for active debris removal by a dual-arm space robot

, 2021
Dong Seop Han, Gangqi Dong, Panfeng Huang, Zhiqing Ma   +3 more
openalex   +1 more source