Results 71 to 80 of about 2,778,255 (309)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Dual algebras.

MATHEMATICA SCANDINAVICA, 1986
Eines der grundlegenden Probleme der harmonischen Analyse lokalkompakter Gruppen besteht darin, geeignete Analoga für die Pontryagin-Dualität im nichtabelschen Fall zu finden. Hier wird man nun keine Dualität zwischen Gruppen erwarten dürfen, weil die dualen Objekte keine Gruppen mehr sind.
openaire   +2 more sources

Dual multifractal spectra [PDF]

Physical Review E, 2004
The multifractal formalism characterizes the scaling properties of a physical density rho as a function of the distance L. To each singularity alpha of the field is attributed a fractal dimension for its support f(alpha). An alternative representation has been proposed by Jensen considering the distribution of distances associated to a fixed mass ...
Roux, S, Jensen, M.H.
openaire   +3 more sources

Radiation and Dual Checkpoint Blockade Activates Non-Redundant Immune Mechanisms in Cancer

Nature, 2015
Immune checkpoint inhibitors result in impressive clinical responses, but optimal results will require combination with each other and other therapies. This raises fundamental questions about mechanisms of non-redundancy and resistance.
Christina Twyman-Saint Victor, A. Rech, A. Maity, Ramesh Rengan, Ramesh Rengan, Kristen E. Pauken, Erietta Stelekati, Joseph L. Benci, Bihui Xu, Hannah Dada, P. Odorizzi, R. Herati, Kathleen D. Mansfield, D. Patsch, R. Amaravadi, L. Schuchter, Hemant Ishwaran, R. Mick, D. Pryma, Xiaowei Xu, M. Feldman, T. Gangadhar, S. Hahn, E. Wherry, R. Vonderheide, A. Minn   +25 more
semanticscholar   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

QCD dual

Physical Review D, 2009
RevTeX, 13 pages. Added discussion on operator matching and flavor decoupling.
openaire   +4 more sources

Dual‐horizon peridynamics [PDF]

International Journal for Numerical Methods in Engineering, 2016
SummaryIn this paper, we develop a dual‐horizon peridynamics (DH‐PD) formulation that naturally includes varying horizon sizes and completely solves the ‘ghost force’ issue. Therefore, the concept of dual horizon is introduced to consider the unbalanced interactions between the particles with different horizon sizes.
Ren, Huilong, Zhuang, Xiaoying, Cai, Yongchang, Rabczuk, Timon   +3 more
openaire   +3 more sources

Paraneoplastic Lupus Nephritis in a Child With Neuroblastoma Recurrence

Pediatric Blood &Cancer, EarlyView.
Gabriele Mortari, Caterina Costagliola, Marta Nebiolo, Francesca Parisi, Martina Morini, Katia Mazzocco, Gabriele Gaggero, Stefano Volpi, Stefania Sorrentino, Virginia Livellara   +9 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source