Results 191 to 200 of about 1,772 (253)

Optimized New Shengmai Powder suppresses ferroptosis in ischemic cardiomyocytes via cGMP-PKG signalling. [PDF]

Chin Med
Zhang Z, Yang Z, Jia Z, Song Y, Guo L, Wang S, Wang X, Mao J.   +7 more
europepmc   +1 more source

ETV1/TGF‐β/SMAD4‐CTGF Axis Activated Tumor‐CAFs Crosstalk Promotes Poor Progression in Hepatocellular Carcinoma Patients

Cancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT The transcription factor ETV1 plays a critical oncogenic role in tumors; its function in cancer‐associated fibroblasts (CAFs) remains poorly understood. We identified a positive correlation between ETV1 and CAFs infiltration in TIMER2.0, and overexpressed ETV1 predicted a poor prognosis in patients from TCGA.
Tongwang Yang, Yiqiang Pang, Jiang Zhou, Hongde Li   +3 more
wiley   +1 more source

Vobramitamab duocarmazine, an anti–B7‐H3 antibody–drug conjugate, in patients with advanced solid tumors: Final results of a phase 1 cohort expansion

Cancer, Volume 132, Issue 15, 1 August 2026.
Abstract Background Vobramitamab duocarmazine is an investigational antibody–drug conjugate (ADC) targeting B7 homolog 3 (B7‐H3) with a cytotoxic duocarmycin‐based DNA‐alkylating payload. This study evaluated its safety and antitumor activity in advanced solid tumors.
Eugene Shenderov, Manish R. Sharma, Elena Garralda, John Powderly, Iwona Ługowska, Alexander Spira, Marc Cucurull Salamero, Sekwon Jang, Rasha Cosman, John Shen, Wen Xu, Piotr J. Wysocki, Rodryg Ramlau, Emmanuel S. Antonarakis, Andrew J. Weickhardt, Jakub Żołnierek, Emiliano Calvo, Enxu Zhao, Chet Bohac, Ashley Ward, Girish Mallesara   +20 more
wiley   +1 more source

Development of polymyxin- and aminoglycoside-based outer membrane permeabilizers: a review. [PDF]

Front Microbiol
Ramirez DM, Schweizer F.
europepmc   +1 more source

Mapping the Phenotypic Spectrum of Occipital Lobe Epilepsy: A SEEG‐Defined Network Classification

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
This SEEG‐based study identifies four propagation patterns in occipital lobe epilepsy (restricted, ventral–limbic, dorsal/DMN–limbic, and lateral TPOJ) linked to five clinical phenotypes. Seizure semiology is shaped by pathway‐selective propagation rather than the onset zone alone, providing a network‐based framework for personalized surgical planning.
Changquan Wang, Wenzhe Chen, Jing Hong, Ziyu Mao, Wenzhen Chen, Jiwen Xu   +5 more
wiley   +1 more source

Dual-targeted manganese-doped carbon dots activate the cGAS-STING pathway and immunogenic cell death for potent glioblastoma immunotherapy. [PDF]

Mater Today Bio
Li Z, Yu C, Che H, Xu D, Lu D, Wang Y, Li X, Ma S, Zhang X, Zhang Z, Yu R.   +10 more
europepmc   +1 more source

Recombinant Artemin‐Fc Fusion Protein Attenuates TLR4/NF‐κB‐Associated Neuroinflammation and Modulates Inhibitory/Excitatory Synaptic Marker Expression After Spinal Cord Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
Intrathecal ARTN‐Fc treatment attenuates TLR4/NF‐κB‐associated neuroinflammation, promotes microglia/macrophage polarization towards an anti‐inflammatory phenotype, and improves functional recovery after spinal cord injury. ARTN‐Fc also modulates inhibitory/excitatory synaptic marker expression in the L4–L5 spinal dorsal horn, which may contribute to ...
Wenjie Lu, Yurong Tu, Renkai Wang, Minghao Jiang, Junyu Zhuang, Jiahui Song, Ping Wu, Sunren Sheng, Sipin Zhu, Zhouguang Wang   +9 more
wiley   +1 more source

Clonal Metamorphosis: Deconstructing MPN Evolution with Single-Cell and Spatial Multi-Omics. [PDF]

Clin Exp Med
Iqbal MS, Alahmari AK, Khan MF, Farooqui S, Iqbal MZ, Khan SU, Khan N, Seshadri VD, Abdelgawwad El-Sehrawy AAM.   +8 more
europepmc   +1 more source

From Ship to Shore: A Review of Vessel‐To‐Grid Bidirectional Charging for Sustainable Maritime Transport

EcoEnergy, Volume 4, Issue 4, August 2026.
As maritime transport electrifies, bidirectional charging (V2G) offers a dual‐purpose solution for energy resilience and economic viability. This work identifies key technological advancements and lifecycle challenges utilizing practical case studies to demonstrate how V2G systems can drive decarbonization and grid stability in the marine sector ...
Jonathan Bloor, Tamer Kamel, Sarah Fear, Lee J. Durndell   +3 more
wiley   +1 more source

De-repression of protein phosphatase 5 by the chaperone organizer HOP1 activates plant NLR immunity. [PDF]

Nat Plants
Yan Y, Zhao Z, Yeo IC, Liu J, de Souza Vespoli L, Liu G, Ye S, Nandakumar J, Shan L, He P.   +9 more
europepmc   +1 more source