Results 101 to 110 of about 906,823 (306)
Nature Communications, 2017 A number of nanomaterials for dual diagnostic and therapeutic application have a number of limitations including poor signal-to-noise ratio. Here, the authors developed dual stimuli-responsive and reversibly activatable nanoprobes for tumour targeting ...
Xu Zhao +3 more
doaj +1 more source
A Study on Dual Hyperbolic Fibonacci and Lucas Numbers
Analele Universitatii "Ovidius" Constanta - Seria Matematica, 2019 Abstract In this study, the dual-hyperbolic Fibonacci and dual-hyperbolic Lucas numbers are introduced. Then, the fundamental identities are proven for these numbers. Additionally, we give the identities regarding negadual-hyperbolic Fibonacci and negadual-hyperbolic Lucas numbers.
Arzu Cihan +3 more
openaire +5 more sources
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
A Markov Model for MIMO Channel Condition Number with Application to Dual-Mode Antenna Selection [PDF]
, 2007 Ping-Heng Kuo +2 more
openalex +1 more source
Dual-Complex Numbers And Their Holomorphic Functions
viXra, 2013 The purpose of this paper is to contribute to development a general theory of dual-complex numbers. We start by de ne the notion of dual- complex and their algebraic properties. In addition, we develop a simple mathematical method based on matrices, simplifying manipulation of dual-complex numbers.
openaire +2 more sources
Molecular Oncology, EarlyView.Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner +6 more
wiley +1 more source
Dual copy number variants involving 16p11 and 6q22 in a case of childhood apraxia of speech and pervasive developmental disorder [PDF]
, 2012 Dianne F. Newbury +9 more
openalex +1 more source
Molecular Oncology, EarlyView.Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva +5 more
wiley +1 more source