Results 101 to 110 of about 3,084,967 (323)
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
CoNfasTT: A Configurable, Scalable, and Fast Dual Mode Logic-Based NTT Design
IEEE AccessThis paper presents a scalable, fully-unrolled Number Theory Transform (NTT) architecture that eliminates memory registers. This architecture leverages Dual-Mode Logic (DML) technology to achieve configurability for various input sizes $(N)$ and bit ...
Eldar Cohen +4 more
doaj +1 more source
Weyl denominator identity for affine Lie superalgebras with non-zero dual Coxeter number [PDF]
, 2009 Maria Gorelik
openalex +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
Dual Hyperbolic Generalized Adrien Numbers
Asian Research Journal of MathematicsThis study introduces the generalized dual hyperbolic Adrien numbers, a novel extension of the classic Adrien framework, enriched by dual and hyperbolic algebraic structures. These sequences are constructed within a fourth-order linear recurrence system, offering intricate mathematical behavior and promising structural versatility. Special attention is
Feyza Demirci, Yüksel Soykan
openaire +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Nature Communications, 2017 A number of nanomaterials for dual diagnostic and therapeutic application have a number of limitations including poor signal-to-noise ratio. Here, the authors developed dual stimuli-responsive and reversibly activatable nanoprobes for tumour targeting ...
Xu Zhao +3 more
doaj +1 more source