Results 111 to 120 of about 10,954,613 (300)
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source
The Dual Neighborhood Number of a Graph [PDF]
, 2010 A set S ⊆ V (G) is a neighborhood set of a graph G = (V,E), if G = v∈SN[v] , where N[v] is the sub graph of a graph G induced by v and all vertices adjacent to v. The dual neighborhood number η+2(G) = Min.
Chaluvaraju, . B +2 more
core +1 more source
Comparing the paths of Hedgehog release in artificial and natural settings
FEBS Letters, EarlyView.Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley +1 more source
Probabilistic analysis of algorithms for dual bin packing problems [PDF]
In the dual bin packing problem, the objective is to assign items of given size to the largest possible number of bins, subject to the constraint that the total size of the items assigned to any bin is at least equal to 1.
Rinnooy Kan, A.H.G. +3 more
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
On the Dual Drazin Inverse of Adjacency Matrices of Dual-number-Weighted Digraphs
CoRRThe motivation of this paper is to investigate the dual Drazin inverse of adjacency matrices arising from several classes of connected dual-number-weighted digraphs over the dual complex algebra. Explicit formulas for the dual Drazin inverse of dual complex anti-triangular block matrices are derived under suitable assumptions. These results are applied
Yue Zhao +3 more
openaire +3 more sources
Dual-flow continuous culture system right view.
, 2016 Dual-flow continuous culture system right view.
Antonio Pinheiro Faciola (829394) +9 more
core +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source