Results 131 to 140 of about 10,954,613 (300)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Dual-perspective approach to potential risk factors.

, 2019
Dual-perspective approach to potential risk factors.
Andrea Arcangeli (506501), Luciana Teofili (3143712), Massimo Antonelli (8610), Rita Gaspari (6321023), Gianfranco Paiano (6321032), Paolo Maurizio Soave (6321029), Alfonso Wolfango Avolio (6321020), Giuseppe Bianco (294458), Giorgia Spinazzola (6321026), Nicola Nicolotti (6243656), Alessandra Gioia Francesconi (6321035)   +10 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Comparative efficacy of human chorionic gonadotropin alone versus dual trigger for oocyte maturation in advanced maternal age using the antagonist protocol: a randomized controlled trial

Journal of Ovarian Research
Background The dual trigger, combining a gonadotropin-releasing hormone agonist with hCG, is reported to improve number of mature oocytes, and cumulative live birth rates.
Isarin Thanaboonyawat, Kittidech Phukittiwarangkul, Pattraporn Chera-Aree, Pitak Laokirkkiat   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Same digits, different magnitudes: manual reaching unveils dual systems in symbolic number representation

BMC Psychology
The role of Approximate Number System (ANS) in adult symbolic number processing remains controversial. Despite evidences for a linear and precise representation of symbolic numbers in adults, this study, based on Dual-Process Theory (DPT), proposes that ...
Danni Liang, Yuanyuan Wang, Zhongting Chen, Ciping Deng   +3 more
doaj   +1 more source

Advances in Measurements of Electron Density and Effective Atomic Number Using Dual-energy Computed Tomography

CT Lilun yu yingyong yanjiu
Accurate measurements of electron density and effective atomic number are essential for precise imaging diagnosis and dose estimation in the multiparametric functional analysis of dual-energy computed tomography (CT).
Xinliang LU, Yunfu LIU, Yongxian ZHANG, Dandan LIU, Yantao NIU   +4 more
doaj   +1 more source

Dual Generalized Pandita Numbers

Asian Journal of Advanced Research and Reports
In this paper, we introduce the dual generalized Pandita numbers defined over the bidimensional Clifford algebra of hyperbolic numbers. As special cases, we examine the dual Pandita and dual Pandita Lucas numbers. We derive Binet formulas, construct generating functions, and establish summation identities for these sequences.
Fatih Zahid Kalca, Yuksel Soykan
openaire   +1 more source

Dual-sector university cohesion: a discussion paper

, 2010
The Dual-Sector University Collaboration Project investigates the ways that the dual-sector universities could evolve to become more cohesive, effective and agile organisations that build upon the connection between their Technical and Further Education (
Peter Matthews (741933), Dale Murphy (19107533)   +1 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source