Results 111 to 120 of about 2,894,253 (306)

Dual-stimuli responsive and reversibly activatable theranostic nanoprobe for precision tumor-targeting and fluorescence-guided photothermal therapy

Nature Communications, 2017
A number of nanomaterials for dual diagnostic and therapeutic application have a number of limitations including poor signal-to-noise ratio. Here, the authors developed dual stimuli-responsive and reversibly activatable nanoprobes for tumour targeting ...
Xu Zhao, Cheng-Xiong Yang, Li-Gong Chen, Xiu-Ping Yan   +3 more
doaj   +1 more source

Discussion: “Application of Dual-Number Quaternion Algebra to the Analysis of Spatial Mechanisms” (Yang, A. T., and Freudenstein, F., 1964, ASME J. Appl. Mech., 31, pp. 300–308) [PDF]

, 1965
J. S. Beggs
openalex   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Discussion: “Analysis of an Offset Unsymmetric Gyroscope With Oblique Rotor Using (3×3) Matrices With Dual-Number Elements” (Yang, An Tzu, 1969, ASME J. Eng. Ind., 91, pp. 535–541) [PDF]

, 1969
L. Maunder
openalex   +1 more source

A Study on Dual Hyperbolic Fibonacci and Lucas Numbers

Analele Universitatii "Ovidius" Constanta - Seria Matematica, 2019
Abstract In this study, the dual-hyperbolic Fibonacci and dual-hyperbolic Lucas numbers are introduced. Then, the fundamental identities are proven for these numbers. Additionally, we give the identities regarding negadual-hyperbolic Fibonacci and negadual-hyperbolic Lucas numbers.
Arzu Cihan, Azak, Ayşe Zeynep, Güngör, Mehmet Ali, Tosun, Murat   +3 more
openaire   +5 more sources

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Evaluation of KRAS and NRAS mutations in metastatic colorectal cancer: an 8‐year study of 10 754 patients in Turkey

Molecular Oncology, EarlyView.
This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci, Izzet Akiva, Yavuz Hakan Ozon, Hakan Berkil, Huseyin Karadayi, Omer Dizdar, Suayib Yalcin   +6 more
wiley   +1 more source

A Markov Model for MIMO Channel Condition Number with Application to Dual-Mode Antenna Selection [PDF]

, 2007
Ping-Heng Kuo, Peter J. Smith, L.M. Garth   +2 more
openalex   +1 more source