Results 151 to 160 of about 906,823 (306)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Combined SNP parental haplotyping and intensity analysis identifies meiotic and mitotic aneuploidies and frequent segmental aneuploidies in preimplantation human embryos. [PDF]

Sci Rep
Handyside AH, Newnham L, Newnham M, Henning D, Velebny J, Pozdena J, Krmelova J, Horak J.   +7 more
europepmc   +1 more source

On dual bicomplex numbers and their some algebraic properties

, 2019
The object of this work is to contribute to the development of bicomplex numbers. For this purpose, in this study we firstly introduced bicomplex numbers with coefficients from complex Fibonacci sequence. And then, using Babadag's work[1], we examined the dual form of the newly defined numbers.
Halıcı, Serpil, Çürük, Şule
openaire   +2 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Effect of Ovarian Stimulation and Trigger Protocols on Oocyte and Embryo Numbers-Real World Experience. [PDF]

J Clin Med
Somer S, Nothman S, Baram S, Izhaki I, Sela ND, Beck-Fruchter R.   +5 more
europepmc   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Effectiveness of Cleaning Methods for Resilient Denture Liners: A Three-Period Randomized Crossover Trial. [PDF]

Clin Exp Dent Res
Takeuchi R, Miyamae S, Sonobe N, Hattori H, Morinaga Y, Hotta H, Hasegawa Y, Kimoto S.   +7 more
europepmc   +1 more source

Duality between prime factors and the Prime Number Theorem for Arithmetic Progressions -- II [PDF]

Krishnaswami Alladi, Jason K. Johnson
openalex   +1 more source

A guide to reactive oxygen species in tumour hypoxia: measurement and therapeutic implications

Molecular Oncology, EarlyView.
Hypoxia reshapes tumour redox landscapes by altering compartmental ROS production (mitochondria, NOX, ER, peroxisomes). Accurate interpretation requires oxygen‐contextualised measurement (live biosensors, chemical probes, EPR, LC–MS) and awareness of artefacts (reoxygenation, probe specificity).
Lina Hacker, Elysia Sarsam, Stuart J. Conway, Ester M. Hammond   +3 more
wiley   +1 more source

11-bit two-dimensional floating-gate memories. [PDF]

Nat Commun
Wang Y, Cai Y, Wang F, Yan T, Li S, Cao M, Hong R, Zhai B, Xu K, Zhan X, He J, Wang Z.   +11 more
europepmc   +1 more source