Results 161 to 170 of about 906,823 (306)

A dual number formulation to efficiently compute higher order directional derivatives [PDF]

R. Peón-Escalante, K. B. Cantún-Avila, O. Carvente, A. Espinosa-Romero, F. Peñuñuri   +4 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Neurovascular de-coupling underlies dual-task cost across cognitive abilities. [PDF]

Alzheimers Dement (N Y)
Fitzgibbon-Collins LK, Best S, Noguchi M, Guest C, Borrie M, Shoemaker JK, Bhangu J.   +6 more
europepmc   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Effects of exercise-cognitive dual-task training on cognitive frailty in older adults: a randomized controlled trial. [PDF]

Front Aging Neurosci
Lai X, Zhu H, Cai Y, Chen B, Li Y, Du H, Zhang L, Wang W, Li S, Huo X.   +9 more
europepmc   +1 more source

Preparation and characterization of renal cell peptides from fetal rats for their antitumor activity

FEBS Open Bio, EarlyView.
This study aimed to prepare renal cells (RCs) from fetal rats which were digested by enzymes. Candidate peptides RCPs were characterized by capillary HPLC and MS and their bioactivity was predicted using peptideranker. The predicted top 10 bioactive peptides were synthesized.
Zhe Zhang, Yuan Cao, Jing Du, Ying Zhang, Junxia Wang, Ying Yuan, Lianqing Sun   +6 more
wiley   +1 more source

Divided attention and manual visuomotor control in stroke: a combined dual-task and eye movement study. [PDF]

J Neuroeng Rehabil
Dziezuk E, Le Boterff Q, Van Ravestyn C, Mairesse S, Hamdoun S, Calvet D, Daghsen L, Carment L, Rosso C, Maier MA, Turc G, Mas JL, G Lindberg P.   +12 more
europepmc   +1 more source

Phenotypic plasticity in a novel set of EGFR tyrosine kinase inhibitor‐adapted non‐small cell lung cancer cell lines

FEBS Open Bio, EarlyView.
Phenotypic plasticity in a newly established set of EGFR inhibitor‐adapted NSCLC cell lines during adaptation and in established cell lines. Here, we introduce novel sublines of the EGFR‐mutant non‐small cell lung cancer (NSCLC) cell lines HCC827 and HCC4006 adapted to the EGFR kinase inhibitors gefitinib (HCC827rGEFI2μm, HCC4006rGEFI1μm), erlotinib ...
Tharsagini V. Nanthaprakash, Campbell W. Gourlay, Ina Oehme, Michelle D. Garrett, Jindrich Cinatl Jr, Mark N. Wass, Martin Michaelis   +6 more
wiley   +1 more source

Microfocused Ultrasound With Visualization for Body Indications: A Global Expert Consensus on Best Practices for Treatment of the Abdomen and Arms. [PDF]

J Cosmet Dermatol
Lin F, Vachiramon V, Casabona G, Cheung J, da Cunha ALG, Pavicic T, Spada J, Fabi S.   +7 more
europepmc   +1 more source

Chinese National Library Classification Number: TM933 Document Identification Code: A Electricity Metering Technology for Power Grid Terminals Considering Dual Carbon Clean Energy [PDF]

Xiaolong Cheng, Zhou Mingli, Xiaojun Li, Zou Tongyang, Men Siyu, Chen Lin   +5 more
openalex   +1 more source