Results 71 to 80 of about 2,526,690 (285)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Erlangen Program at Large-1: Geometry of Invariants
Symmetry, Integrability and Geometry: Methods and Applications, 2010 This paper presents geometrical foundation for a systematic treatment of three main (elliptic, parabolic and hyperbolic) types of analytic function theories based on the representation theory of SL_2(R) group. We describe here geometries of corresponding
Vladimir V. Kisil
doaj +1 more source
Transmathematica, 2019 The class of dual number meadows is introduced. By definition this class is a quasivariety. Dual number meadows contain a non-zero element the square of which is zero. These structures are non-involutive and coregular. Some properties of the equational theory of dual number meadows are discussed and an initial algebra specification is given for the ...
openaire +3 more sources
Radix form in hyperbolic and dual numbers [PDF]
, 2022 We investigate number systems for the ring of integers of hyperbolic and dual numbers. We characterize all canonical number systems providing radix form for hyperbolic and dual numbers.
Kossentini, Sayed
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Dr. Don & Family Numbers Folder
, 1960 6 pages of family history documents containing and related to Dr. Don Numbers; Zoe Numbers; Murray (Muddy) Numbers & Jack Numbers - including: Payette Lakes Historical Club,The ...
Dr. Don Numbers; Zoe Numbers; Murray (Muddy) Numbers & Jack Numbers
core
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source