Results 71 to 80 of about 2,644,466 (335)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Integrated Dynamics of Space Rigid-Flex Combination System with Time-Varying Configuration

International Journal of Aerospace Engineering, 2023
Dual numbers were applied to the dynamics of a rigid-flexible combination system (RFCS) with time-varying configuration in this paper. The six-dimensional spinor form of the motion of flexible modules, including the dual vector, dual momentum, dual ...
Yaen Xie, Xianliang Zhang, Xiangshuai Song, Xiaobin Lian, Jian Zhang   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Dual quaternion representation of points, lines and planes

Discrete and Continuous Models and Applied Computational Science
Background. The bulk of the work on dual quaternions is devoted to their application to describe helical motion. Little attention is paid to the representation of points, lines, and planes (primitives) using them. Purpose. It is necessary to consistently
Migran N. Gevorkyan, Nikita A. Vishnevskiy, Kirill V. Didus, Anna V. Korolkova, Dmitry S. Kulyabov   +4 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

On a New Generalization of Pell Hybrid Numbers

Annales Mathematicae Silesianae
In this paper, we define and study a new one-parameter generalization of the Pell hybrid numbers. Based on the definition of r-Pell numbers, we define the r-Pell hybrid numbers.
Bród Dorota, Szynal-Liana Anetta, Włoch Iwona   +2 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Erlangen Program at Large-1: Geometry of Invariants

Symmetry, Integrability and Geometry: Methods and Applications, 2010
This paper presents geometrical foundation for a systematic treatment of three main (elliptic, parabolic and hyperbolic) types of analytic function theories based on the representation theory of SL_2(R) group. We describe here geometries of corresponding
Vladimir V. Kisil
doaj   +1 more source

Dual Number Meadows

Transmathematica, 2019
The class of dual number meadows is introduced. By definition this class is a quasivariety. Dual number meadows contain a non-zero element the square of which is zero. These structures are non-involutive and coregular. Some properties of the equational theory of dual number meadows are discussed and an initial algebra specification is given for the ...
openaire   +3 more sources