Results 81 to 90 of about 4,249,593 (344)
FEBS Letters, EarlyView.Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello +6 more
wiley +1 more source
Integrated Dynamics of Space Rigid-Flex Combination System with Time-Varying Configuration
International Journal of Aerospace Engineering, 2023 Dual numbers were applied to the dynamics of a rigid-flexible combination system (RFCS) with time-varying configuration in this paper. The six-dimensional spinor form of the motion of flexible modules, including the dual vector, dual momentum, dual ...
Yaen Xie +4 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
An Extended Fuzzy TODIM Approach for Multiple-Attribute Decision-Making with Dual-Connection Numbers
Advances in Fuzzy Systems, 2020 The TODIM is a decision-making method that can examine the psychological behavior of decision-makers (DMs). However, the traditional TODIM method has still not been having the ability to overcome fuzzy information such as interval values and linguistic ...
I. Irvanizam +4 more
semanticscholar +1 more source
The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity
FEBS Letters, EarlyView.The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley +1 more source
Hyper–Dual Numbers: A Theoretical Foundation for Exact Second Derivatives
MathematicsSecond-order derivative information, including mixed curvature, is central to Newton and trust-region optimization, uncertainty quantification, and simulation-based design.
Sung Bum Park, Ji Eun Kim
doaj +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
, 2022 In the present paper, the hyper-dual Leonardo numbers will be introduced with the use of Leonardo numbers. Some algebraic properties of these numbers such as recurrence relation, generating function, Catalan’s and Cassini’s identity, Binet’s formula, sum formulas will also be obtained.
ÖZKALDI KARAKUŞ, Sıddıka +2 more
openaire +2 more sources
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Euclidean scissor congruence groups and mixed Tate motives over dual numbers [PDF]
, 2004 We define Euclidean scissor congruence groups for an arbitrary algebraically closed field F and propose their conjectural description. We suggest how they should be related to mixed Tate motives over dual numbers for F.
Alexander Goncharov
semanticscholar +1 more source