Results 91 to 100 of about 1,808,891 (305)

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Synergistic improvement of strength and ductility in additively manufactured in-situ phase-transitioned dual-phase hetero-structures

Materials Research Letters
Laser powder bed fusion additive manufacturing offers unique advantages for constructing dual-phase heterogeneous structural materials. This study employed mechanically mixed powders to successfully fabricate dual-phase heterogeneous alloys exhibiting ...
Guoqing Huang, Haitao Yang, Jianrui Zhang, Bo Li   +3 more
doaj   +1 more source

Design of Dual-band Branch-Line Coupler Based on Shunt Open-Circuit DCRLH Cells [PDF]

, 2013
In this article, the shunt open-circuit dual composite right/left-handed (DCRLH) cell is initially proposed and one dual-band branch-line coupler based on the proposed cells is designed.
Bo Tian, Guang-Ming Wang, Ke Lu
core  

Re-entrant magnetic field induced charge and spin gaps in the coupled dual-chain quasi-one dimensional organic conductor Perylene$_2$[Pt(mnt)$_2$]

, 2013
An inductive method is used to follow the magnetic field-dependent susceptibility of the coupled charge density wave (CDW) and spin-Peierls (SP) ordered state behavior in the dual chain organic conductor Perylene$_2$[Pt(mnt)$_2$].
Almeida, M., Benjamin, S., Bourbonnais, C., Brooks, J. S., Schlottmann, P., Winter, L. E.   +5 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The effects of forging strategies on microstructures and mechanical properties of a Ti–5Al–5Mo–5V–1Cr–1Fe near β-titanium alloy

Journal of Materials Research and Technology
The present study systematically investigated the influence of forging strategies on the microstructures and deformation behaviors of a Ti–5Al–5Mo–5V–1Cr–1Fe (Ti-55511) near β-titanium alloy.
Xianghong Liu, Xiaolong Ren, Xinglong An, Yu Chen, Tao Wang, Song Ni, Min Song, Hao Zhang, Yuxuan Du   +8 more
doaj   +1 more source

The peak current control of permanent magnet brushless DC machine with asymmetric dual-three phases

CES Transactions on Electrical Machines and Systems, 2018
The asymmetric dual-three phase BLDC motor has two sets of stator windings, in which the back EMF coefficients are different. This paper takes advantage of the asymmetric dual-three phase BLDC motor's structural features and proposes a new method for the
Chunyuan Bian, Xiaoxia Li, Guannan Zhao
doaj   +1 more source

Four-Port Dual-Mode Diplexer with High Signal Isolation

Active and Passive Electronic Components, 2020
An ease of four-port dual-mode diplexer with high signal isolation is presented. A compact dual-mode diplexer with high signal isolation between the Rx and Tx modules is achievable by only using one resonator filter topology.
Jessada Konpang, Natchayathorn Wattikornsirikul   +1 more
doaj   +1 more source