Results 71 to 80 of about 574,724 (266)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Synergistic improvement of strength and ductility in additively manufactured in-situ phase-transitioned dual-phase hetero-structures

open access: yesMaterials Research Letters
Laser powder bed fusion additive manufacturing offers unique advantages for constructing dual-phase heterogeneous structural materials. This study employed mechanically mixed powders to successfully fabricate dual-phase heterogeneous alloys exhibiting ...
Guoqing Huang   +3 more
doaj   +1 more source

Four-Port Dual-Mode Diplexer with High Signal Isolation

open access: yesActive and Passive Electronic Components, 2020
An ease of four-port dual-mode diplexer with high signal isolation is presented. A compact dual-mode diplexer with high signal isolation between the Rx and Tx modules is achievable by only using one resonator filter topology.
Jessada Konpang   +1 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

The effects of forging strategies on microstructures and mechanical properties of a Ti–5Al–5Mo–5V–1Cr–1Fe near β-titanium alloy

open access: yesJournal of Materials Research and Technology
The present study systematically investigated the influence of forging strategies on the microstructures and deformation behaviors of a Ti–5Al–5Mo–5V–1Cr–1Fe (Ti-55511) near β-titanium alloy.
Xianghong Liu   +8 more
doaj   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

open access: yesFEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

The peak current control of permanent magnet brushless DC machine with asymmetric dual-three phases

open access: yesCES Transactions on Electrical Machines and Systems, 2018
The asymmetric dual-three phase BLDC motor has two sets of stator windings, in which the back EMF coefficients are different. This paper takes advantage of the asymmetric dual-three phase BLDC motor's structural features and proposes a new method for the
Chunyuan Bian, Xiaoxia Li, Guannan Zhao
doaj   +1 more source

An N = 2 dual pair and a phase transition [PDF]

open access: yesNuclear Physics B, 1996
LaTeX, 21 pages, minor ...
openaire   +2 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

open access: yesFEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı   +4 more
wiley   +1 more source

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