Results 31 to 40 of about 152,028 (255)

When Type 2 Processing Misfires: The Indiscriminate Use of Statistical Thinking about Reasoning Problems

Journal of Intelligence, 2022
Research on dual-process theories of judgment makes abundant use of reasoning problems that present a conflict between Type 1 intuitive responses and Type 2 rule-based responses.
Mário B. Ferreira, Jerônimo C. Soro, Joana Reis, André Mata, Valerie A. Thompson   +4 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Sequential deconfinement in 3d N $$ \mathcal{N} $$ = 2 gauge theories

Journal of High Energy Physics, 2021
We consider 3d N $$ \mathcal{N} $$ = 2 gauge theories with fundamental matter plus a single field in a rank-2 representation. Using iteratively a process of “deconfinement” of the rank-2 field, we produce a sequence of Seiberg-dual quiver theories.
Sergio Benvenuti, Ivan Garozzo, Gabriele Lo Monaco   +2 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Judging fast and slow: The truth effect does not increase under time-pressure conditions

Judgment and Decision Making, 2021
Due to the information overload in today’s digital age, people may sometimes feel pressured to process and judge information especially fast. In three experiments, we examined whether time pressure increases the repetition-based truth effect — the ...
Lena Nadarevic, Martin Schnuerch, Marlena J. Stegemann   +2 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Mindfulness as a Buffer of Leaders’ Self-Rated Behavioral Responses to Emotional Exhaustion: A Dual Process Model of Self-Regulation

Frontiers in Psychology, 2018
In this study, we investigate the self-regulatory role of mindfulness in buffering the relationship between leaders’ emotional exhaustion and self-rated leadership behavior (transformational leadership and abusive supervision).
Megan M. Walsh, Kara A. Arnold
doaj   +1 more source