Results 71 to 80 of about 150,972 (303)

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Is there a correlation between sensory impairments and social isolation in middle-aged and older Chinese population? Cross-sectional and longitudinal evidence from a nationally representative survey

Frontiers in Public Health, 2023
PurposeThe aim of this study is to investigate the cross-sectional and longitudinal associations between sensory impairments (SIs) including single vision impairment (SVI), single hearing impairment (SHI), and dual sensory impairments (DSI) with social ...
Ye Liu, Ye Liu, Ye Liu, Qinglei Sun, KaiweiSa Abuduxukuer, KaiweiSa Abuduxukuer, KaiweiSa Abuduxukuer, Yanan Hou, Yanan Hou, Jin Wei, Jin Wei, Haiyun Liu, Haiyun Liu, Jianfeng Luo, Jianfeng Luo, Jianfeng Luo, Guangfeng Gao, Yifan Zhou   +17 more
doaj   +1 more source

EXAMINING QUALITY INDICATOR RATES FOR OLDER HOME CARE CLIENTS WITH DUAL SENSORY IMPAIRMENT (DSI) AND EXPLORING THE HETEROGENEITY WITHIN DSI. [PDF]

, 2016
Older adults with impairments in both hearing and vision, called dual sensory impairment (DSI), are at an increased risk of negative health outcomes such as impaired communication and difficulties with mobility.
Davidson, Jacob G S, Guthrie, Dawn M.
core   +1 more source

Effect of supervised exercise on physical function and balance in patients with intermittent claudication [PDF]

, 2014
Background The aim of the study was to identify whether a standard supervised exercise programme (SEP) for patients with intermittent claudication improved specific measures of functional performance including balance. Methods A prospective observational
Chetter, I. C., Coughlin, P. A., Gohil, R. A., Khan, J. A., Mazari, F., Mockford, K. A., Vanicek, N.   +6 more
core   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Theories of developmental dyslexia: Insights from a multiple case study of dyslexic adults [PDF]

, 2002
A multiple case study was conducted in order to assess three leading theories of developmental dyslexia: the phonological, the magnocellular (auditory and visual) and the cerebellar theories.
Castellote, Juan M., Dakin, Steven C., Day, Brian L., Frith, Uta, Ramus, Franck, Rosen, Stuart, White, Sarah   +6 more
core   +3 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Impact of single and dual sensory impairments on cognitive function and psychological well-being among older adults in Upper Egypt

Archives of Gerontology and Geriatrics Plus
Background: Dual sensory impairment (DSI), involving both vision and hearing loss, is increasingly recognized as a significant contributor to poor psychological health and cognitive decline in older adults.
Rasha Ahmed Fouad, Esteer Ibrahim Ghayth, Safaa Mostafa Abdeen, Sanaa Mostafa Khalifa   +3 more
doaj   +1 more source