Results 51 to 60 of about 646,982 (285)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

The Lorentz space as a dual space [PDF]

Proceedings of the American Mathematical Society, 1984
If ( X , S , μ ) (X,S,\mu ) is a finite, completely nonatomic measure space and ϕ ( t ) = t 1 / p ( p &
openaire   +1 more source

Images of function and distribution spaces under the Bargmann transform

, 2016
We consider a broad family of test function spaces and their dual (distribution) space. The family includes Gelfand-Shilov spaces, a family of test function spaces introduced by S. Pilipovic.
Toft, Joachim
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Regularity of fuzzy convergence spaces

Open Mathematics, 2018
(Fuzzy) convergence spaces are extensions of (fuzzy) topological spaces. ⊤-convergence spaces are one of important fuzzy convergence spaces. In this paper, we present an extending dual Fischer diagonal condition, and making use of this we discuss a ...
Li Lingqiang, Jin Qiu, Yao Bingxue
doaj   +1 more source

Target space pseudoduality between dual symmetric spaces [PDF]

Nuclear Physics B, 2000
LaTeX, 20 pages.
openaire   +3 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Observations on the Separable Quotient Problem for Banach Spaces

Axioms, 2020
The longstanding Banach−Mazur separable quotient problem asks whether every infinite-dimensional Banach space has a quotient (Banach) space that is both infinite-dimensional and separable.
Sidney A. Morris, David T. Yost
doaj   +1 more source

The Generalized Difference Operator Δi3 of Order Three and Its Domain in the Sequence Spaces ℓ1 and bv

Journal of Mathematics, 2022
Most recently, the generalized difference operator Δi3 of order three was defined and its domain in Hahn sequence space h was calculated. In this paper, the spaces ℓ1Δi3 and bvΔi3 are introduced as the domain of generalized difference operator Δi3 of ...
Orhan Tuğ
doaj   +1 more source