Results 41 to 50 of about 149,447 (303)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Problems with the "Problems" with psychophysical causation [PDF]

open access: yes, 2019
In this essay, I defend a mind-body dualism, according to which human minds are immaterial substances that exercise non-redundant causal powers over bodies, against the notorious problem of psychophysical causation.
McKay, Noah
core  

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Holism, individualism, personalism: from Platonic dualism to the dispute over a source and status of human individuality (N. Elias, I. Berlin, R. Rorty) [PDF]

open access: yesAnaliza i Egzystencja, 2015
Individualism as a way of feeling and comprehension of reality has been a basic element of Western civilization for a long time. In 20th century individualism was criticized by personalism and similar currents.
Zbigniew Ambrożewicz
doaj  

Lagged development and economic dualism

open access: yesPSL Quarterly Review, 2014
The work explores the hypothesis that today’s lagging economies, such as Italy, are not completely lacking in firms that are capable of achieving high levels of productivity, rather they simply do not have enough of them to absorb a sizeable portion of ...
G. FUÀ
doaj   +1 more source

Neuroscience, Spiritual Formation, and Bodily Souls: A Critique of Christian Physicalism [PDF]

open access: yes, 2017
The link between human nature and human flourishing is undeniable. "A healthy tree cannot bear bad fruit, nor can a diseased tree bear good fruit" (Matt. 7:18).
Evans, C. Stephen, Rickabaugh, Brandon
core  

Challenging dualism : public professionalism in ‘troubled’ times [PDF]

open access: yes, 2006
In recent decades neo-liberal reform has significantly impacted on public sector professionals. Sociological interest in such impact has tended to focus on professionals as subjects of such reform: as either de-professionalized ‘victims’ who feel ...
Gleeson, Denis, Knights, David
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The growth process in a "dual" economic system

open access: yesPSL Quarterly Review, 2014
It may be said that the Italian economy has remained - after about three quarters of a century of industrial development along modern lines - roughly half “advanced” and half “primitive”.
V.C. LUTZ
doaj   +1 more source

Not Properly a Person: The Rational Soul and ‘Thomistic Substance Dualism’ [PDF]

open access: yes, 2009
Like Aristotle, Thomas Aquinas holds that the rational soul is the substantial form of the human body. In so doing, he takes himself to be rejecting a Platonic version of substance dualism; his criticisms, however, apply equally to a traditional ...
Van Dyke, Christina
core   +2 more sources

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