Results 91 to 100 of about 529,479 (293)
We review the current status of the construction of unitary representations of U-duality groups of supergravity theories in five, four and three dimensions. We focus mainly on the maximal supergravity theories and on the N=2 Maxwell-Einstein supergravity
Gunaydin, Murat
core +1 more source
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
En bleu et noir, la Méditerranée est-elle toujours un rêve ?
At the usual enthusiasm for the Mediterranean Sea of legends, with its postcard blue and white, it is quite lucid to associate the red of the fire and the blood, as well as the black of the violence and the death, e.g. the tragedy.
Jean-Claude Villain
doaj +1 more source
Personification of a Duality [PDF]
This watercolor self-portrait visually characterizes an irony faced by clinicians who are underrepresented minorities. Tasked with saving patients' lives during the COVID-19 pandemic, they belong to communities inequitably burdened by the SARS-CoV-2 virus and by many Americans' unwillingness to follow public health recommendations that would protect ...
openaire +2 more sources
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
This article investigates robust optimality conditions and duality results for a class of nonsmooth multiobjective programming problems with vanishing constraints under data uncertainty (UNMPVC).
Balendu Bhooshan Upadhyay +3 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source

