Results 101 to 110 of about 40,182 (268)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
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Duality modules and Morita duality
Journal of Algebra, 1989 Let \({}_RU_S\) be endowed with a Hausdorff topology such that the elements of \(S\) induce continuous \(R\)-homomorphisms, \(R\text{-Top}\) be the category of Hausdorff topological left \(R\)-modules. \(U\)-duality between full subcategories \(\mathcal C\subseteq R\)-Top and \(\mathcal D\subseteq \text{Mod-}S\) is defined by functors \(\text{Cont}_R(-,
Zelmanowitz, J.M, Jansen, W
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KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Jordan duality and Freudenthal duality
Journal of Physics: Conference Series, 2013 We define a Jordan duality A → A* on the quantised charges A of five dimensional black holes and strings and an analogous Freudenthal duality x → on the quantised charges x of four dimensional stringy black holes, both of which are distinct from U-duality but leave the lowest order entropy invariant.
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Nuclear Physics B, 1996 We construct several examples where duality transformation commutes with the orbifolding procedure even when the orbifolding group does not act freely, and there are massless states from the twisted sector at a generic point in the moduli space. Often the matching of spectrum in the dual theories is a result of non-trivial identities satisfied by the ...
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Theoretical Economics, 2019 We present a unified duality approach to Bayesian persuasion. The optimal dual variable, interpreted as a price function on the state space, is shown to be a supergradient of the concave closure of the objective function at the prior belief. Strong duality holds when the objective function is Lipschitz continuous.
Dworczak, Piotr, Kolotilin, Anton
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Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source