Results 101 to 110 of about 103,825 (319)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The composite particle duality: a new class of topological quantum matter

open access: yesNew Journal of Physics
The composite particle duality extends the notions of both flux attachment and statistical transmutation in spacetime dimensions beyond 2 + 1D. It constitutes an exact correspondence that can be understood either as a theoretical framework or as a ...
Gerard Valentí-Rojas   +2 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Infinite-dimensional Lie Algebras, Representations, Hermitian Duality and the Operators of Stochastic Calculus

open access: yesAxioms, 2016
We study densely defined unbounded operators acting between different Hilbert spaces. For these, we introduce a notion of symmetric (closable) pairs of operators.
Palle Jorgensen, Feng Tian
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

CEO duality and agency cost: evidence from Bangladesh

open access: yes, 2013
This study examines if Chief Executive Officer (CEO) duality reduces the firms' agency cost in Bangladesh. The agency costs are measured as two efficiency ratios: expense ratio and asset utilization ratio.
Rashid, Afzalur
core   +1 more source

String/Gauge Duality and Penrose Limit [PDF]

open access: yes, 2003
Berenstein, Maldacena, and Nastase have recently discovered a particular limit of AdS/CFT correspondence where string theory in a plane wave background is dual to a sector of $mathcal N =4 SYM in a double scaling limit.
Park, Jongwon
core   +1 more source

Stone duality for spectral sheaves and the patch monad

open access: yes, 2023
We establish a duality between global sheaves on spectral spaces and right distributive bands. This is a sheaf-theoretical extension of classical Stone duality between spectral spaces and bounded distributive lattices.
Gehrke, Mai, Berger, Clemens
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

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