Results 121 to 130 of about 40,182 (268)
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
, 2011 The fact that one can associate a finite monoid with universal properties to each language recognised by an automaton is central to the solution of many practical and theoretical problems in automata theory. It is particularly useful, via the advanced theory initiated by Eilenberg and Reiterman, in separating various complexity classes and, in some ...
openaire +2 more sources
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Optimal Consumption and Investment Problem with Consumption Ratcheting in Luxury Goods
MathematicsThis paper investigates an infinite-horizon optimal consumption and investment problem for an agent who consumes two types of goods: necessities and luxuries.
Geonwoo Kim, Junkee Jeon
doaj +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Word Pairs as Rhetorical Elements in the Qurʾān: In Memoriam Alexander Sima (1969–2004)
ReligionsAnyone who starts reading the Qurʾān out of linguistic and literary interest—whether in the original language or in a translation—very quickly becomes aware of the strong rhetorical effect of the text in its forcefulness and intensity.
Kathrin Müller
doaj +1 more source
FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
Reconstruction of Type II Supergravities via O(d) × O(d) Duality Invariants
UniverseWe reconstruct type II supergravities by using building blocks of O(d)×O(d) invariants. These invariants are obtained by explicitly analyzing O(d)×O(d) transformations of 10 dimensional massless fields.
Yoshifumi Hyakutake, Kiyoto Maeyama
doaj +1 more source
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source