Results 141 to 150 of about 103,825 (319)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Duality and calculi without exceptions for convex objects
The aim of this paper is to make a contribution to theinvestigation of the roots and essence of convex analysis, and tothe development of the duality formulas of convex calculus.
Brinkhuis, J.
core
Canonical Duality Theory for Topology Optimization
, 2017 This paper presents a canonical duality approach for solving a general topology optimization problem of nonlinear elastic structures. Based on the principle of minimum total potential energy, this most challenging problem can be formulated as a bi-level ...
David Yang Gao, Gao, David
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Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Duality Theory for Variable Costs in Joint Production [PDF]
Duality methods for incomplete systems of consumer demand equations are adapted to the dual structure of variable cost functions in joint production. This allows the identification of necessary and sufficient restrictions on technology and cost so that ...
Jeffrey LaFrance, Rulon Pope
core
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Empirical properties of duality theory
This research examines selected empirical properties of duality relationships. Monte Carlo experiments indicate that Hessian matrices estimated from the normalised unrestricted profit, restricted profit and production functions yield conflicting results ...
Featherstone, Allen M. +3 more
core
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
The duality of the nature of dialogue in philosophy and medical practice
Studia Humanitatis, 2019 The article analyses the duality of nature in relationships between the doctor and the patient. This research was conducted in the context of M. Buber’s philosophy.
Koroleva Elena Pavlovna +1 more
doaj
CEO duality and corporate social responsibility reporting: evidence from Malaysia
, 2017 This study aims to examine the impact of CEO duality on Corporate Social Responsibility (CSR) reporting by public listed companies in Malaysia. Content analysis was used to determine the extent of CSR reporting.
Gow, Jeff +2 more
core +1 more source