Results 71 to 80 of about 103,825 (319)
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
We construct dual descriptions of (0,2) gauged linear sigma models. In some cases, the dual is a (0,2) Landau-Ginzburg theory, while in other cases, it is a non-linear sigma model. The duality map defines an analogue of mirror symmetry for (0,2) theories. Using the dual description, we determine the instanton corrected chiral ring for some illustrative
Adams, Allan +2 more
openaire +3 more sources
Sufficient optimality criteria and duality for multiobjective variational control problems with B-(p,r)-invex functions [PDF]
In this paper, we generalize the notion of \(B\)-\((p,r)\)-invexity introduced by Antczak in [A class of \(B\)-\((p; r)\)-invex functions and mathematical programming, J. Math. Anal. Appl. 286 (2003), 187-206] for scalar optimization problems to the case
Tadeusz Antczak, Manuel Arana Jiménez
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
We review and elaborate on the issue of the dilaton transformation under the usual r → α′/r target space duality and its "non-static" generalization (or σ-model duality). It is found that the transformation law r → α′/r, [Formula: see text] which guarantees duality at the one-loop σ-model level should be modified at two (and higher) loop order.
openaire +2 more sources
Human or Animal - Duality and Identity in Indra Sinha's Animal's People
This essay analyzes the figure of Animal in Indra Sinha's novel Animal's ...
Alex Girona Salmerón
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In this paper, we study a nonsmooth semi-infinite multi-objective E-convex programming problem involving support functions. We derive sufficient optimality conditions for the primal problem.
Emam Tarek
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Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Monuments and monumentality: the cosmological model of the world of megaliths
Neolithic monuments are physical and conceptual expressions of ideas about the nature of the world inhabited by early north European farmers. This contribution explores the complex symbolism encoded in megalithic architecture, and the socio-ritual ...
Magdalena S. Midgley
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The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source

