Results 141 to 150 of about 2,001,040 (344)
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Summary Talk on Quark-Hadron Duality
, 2005 I ascribe the origin of Bloom-Gilman duality in DIS to a separation of scales between the hard subprocess and soft resonance formation. The success of duality indicates that the subprocesses of exclusive form factors are the same as in DIS.
Hoyer, Paul
core +2 more sources
Model Selection Criteria Using Divergences
Entropy, 2014 In this note we introduce some divergence-based model selection criteria. These criteria are defined by estimators of the expected overall discrepancy between the true unknown model and the candidate model, using dual representations of divergences and ...
Aida Toma
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Duality relation between coherence and path information in the presence of quantum memory
, 2017 The wave-particle duality demonstrates a competition relation between wave and particle behavior for a particle going through an interferometer. This duality can be formulated as an inequality, which upper bounds the sum of interference visibility and ...
Bu, Kaifeng +3 more
core +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity
Molecular Oncology, EarlyView.Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek +2 more
wiley +1 more source
Las dualidades de la educación The dualities of education
Educación y Educadores, 2007 Este trabajo sostiene que el método de estudio de la educación humana no puede suponer que el hombre sea simple, puesto que está conformado por pluralidad de dualidades. Encuadra la educación dentro de las dualidades radicales humanas. Primero, distingue
Juan Fernando Sellés
doaj
On the use of semi-closed sets and functions in convex analysis
Open Mathematics, 2015 The main aim of this short note is to show that the subdifferentiability and duality results established by Laghdir (2005), Laghdir and Benabbou (2007), and Alimohammady et al. (2011), stated in Fréchet spaces, are consequences of the corresponding known
Zălinescu Constantin
doaj +1 more source