Results 31 to 40 of about 69,844 (255)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Quantum critical transport, duality, and M-theory [PDF]

, 2007
We consider charge transport properties of 2+1 dimensional conformal field theories at non-zero temperature. For theories with only Abelian U(1) charges, we describe the action of particle-vortex duality on the hydrodynamic-to-collisionless crossover ...
Christopher P. Herzog, D. Forster, Dam Thanh Son, E. D’Hoker, E. Witten, M. J. Duff, P. G. O. Freund, Pavel Kovtun, S. Sachdev, S. Sachdev, Subir Sachdev   +10 more
core   +2 more sources

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Topological dualities in the Ising model [PDF]

, 2018
We relate two classical dualities in low-dimensional quantum field theory: Kramers-Wannier duality of the Ising and related lattice models in $2$ dimensions, with electromagnetic duality for finite gauge theories in $3$ dimensions.
Freed, Daniel S, Teleman, Constantin
core  

Moore-Read Fractional Quantum Hall wavefunctions and SU(2) quiver gauge theories

, 2010
We identify Moore-Read wavefunctions, describing non-abelian statistics in fractional quantum Hall systems, with the instanton partition of N=2 superconformal quiver gauge theories at suitable values of masses and \Omega-background parameters.
Santachiara, Raoul, Tanzini, Alessandro
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Conformality and Gauge Coupling Unification [PDF]

, 1999
It has been recently proposed to embed the standard model in a conformal gauge theory to resolve the hierarchy problem, and to avoid assuming either grand unification or low-energy supersymmetry.
A. De Rújula, C. Caso, J. Maldacena, N. Sakai, P.H. Frampton, P.H. Frampton, Paul H. Frampton, S. Dimopoulos, S. Kachru, U. Amaldi, U. Amaldi   +10 more
core   +3 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Dualities in Supersymmetric Field Theories

, 1997
Lectures presented at the 33rd Karpacz Winter School ``Duality: Strings and Fields'' briefly introducing dualities in four-dimensional quantum field theory, and summarizing results found in supersymmetric field theories.
Argyres, Argyres, Argyres, Argyres, Berkooz, Brodie, Dolan, Donagi, Jack, Leigh, Montonen, Novikov, Osborn, Philip C. Argyres, Pouliot, Pouliot, Pouliot, Seiberg, Seiberg, Seiberg, Seiberg, Seiberg, Shifman, Shifman, Sonoda, Sonoda, Vafa, Witten, Witten, Witten   +29 more
core   +2 more sources