Results 51 to 60 of about 114,817,381 (289)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Simplified self-dual electrodynamics

Journal of High Energy Physics
We present a new formulation of self-dual nonlinear electrodynamics in which interactions are determined by an auxiliary-field potential, with causality ensuring a unique solution to the auxiliary-field equation.
Jorge G. Russo, Paul K. Townsend
doaj   +1 more source

From 3d duality to 2d duality

Journal of High Energy Physics, 2017
In this paper we discuss 3d N $$ \mathcal{N} $$ = 2 supersymmetric gauge theories and their IR dualities when they are compactified on a circle of radius r, and when we take the 2d limit in which r → 0. The 2d limit depends on how the mass parameters are
Ofer Aharony, Shlomo S. Razamat, Brian Willett   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Dualties of adjoint QCD3 from branes

Journal of High Energy Physics, 2022
We consider an ‘electric’ U(N) level k QCD3 theory with one adjoint Majorana fermion. Inspired by brane dynamics, we suggest that for k ≥ N/2 the massive m < 0 theory, in the vicinity of the supersymmetric point, admits a U k − N 2 − 1 2 k + 3 4 N , − k +
Adi Armoni
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Dynamical edge modes in p-form gauge theories

Journal of High Energy Physics
We extend our recently identified dynamical edge mode boundary condition to p-form gauge theories, revealing their edge modes as Goldstone bosons arising from gauge transformations with support on the boundary.
Adam Ball, Y. T. Albert Law
doaj   +1 more source

Manifestly SL(2, R) Duality-Symmetric Forms in ModMax Theory

Journal of High Energy Physics, 2022
In this paper, we will investigate a manifestly SL(2, R)-invariant structure for the energy-momentum tensor of ModMax theory as a nonlinear modification of Maxwell electrodynamics which includes conformal invariance as well. In the context of this theory,
H. Babaei-Aghbolagh, Komeil Babaei Velni, Davood Mahdavian Yekta, H. Mohammadzadeh   +3 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Renormalized electric and magnetic charges for O(r n ) large gauge symmetries

Journal of High Energy Physics
In this work we present the construction of a renormalized symplectic form on an extended phases space where the higher order large gauge transformations (LGT) act canonically. The expressions of the sub n -leading electric charges associated with each O(
Javier Peraza
doaj   +1 more source