Results 21 to 30 of about 982,446 (228)
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Baryons, monopoles and dualities in Chern-Simons-matter theories [PDF]
, 2015 There is significant evidence for a duality between (non-supersymmetric) U(N) Chern-Simons theories at level k coupled to fermions, and U(k) Chern-Simons theories at level N coupled to scalars. Most of the evidence comes from the large N 't Hooft limit, where many details of the duality (such as whether the gauge group is U(N) or SU(N), the precise ...
arxiv +1 more source
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Level/rank Duality and Chern-Simons-Matter Theories [PDF]
, 2016 We discuss in detail level/rank duality in three-dimensional Chern-Simons theories and various related dualities in three-dimensional Chern-Simons-matter theories. We couple the dual Lagrangians to appropriate background fields (including gauge fields, spin$_c$ connections and the metric).
arxiv +1 more source
Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM
Molecular Oncology, EarlyView.CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak +14 more
wiley +1 more source
A Duality Between U(1) Haah Code and 3D Smectic A Phase [PDF]
arXiv, 2020 We describe a duality between multipole gauge theories and spatially ordered phases. Our main example is a duality between the multipole gauge theory description of the U(1) Haah code and smectic A phase in three spatial dimensions. We show how multipole symmetries restrict the mobility of dislocations and disclinations in smectic A phase.
arxiv
Higher Cluster Categories and QFT Dualities [PDF]
Phys. Rev. D 98, 046021 (2018), 2017 We present a unified mathematical framework that elegantly describes minimally SUSY gauge theories in even dimension, ranging from $6d$ to $0d$, and their dualities. This approach combines recent developments on graded quiver with potentials, higher Ginzburg algebras and higher cluster categories (also known as $m$-cluster categories). Quiver mutations
arxiv +1 more source
Molecular Oncology, EarlyView.This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.IDMF is a derivative of dimethyl fumarate (DMF) with a unique therapeutic potential at the intersection of psoriasis and multiple sclerosis. Here, we demonstrate that it compares favorably with DMF and its other derivatives, such as Diroximel, in the zebrafish, microglia, and lymphocyte models.
Yulin He +5 more
wiley +1 more source