Results 21 to 30 of about 323,942 (174)

Discrete Symmetries in Heterotic/F-theory Duality and Mirror Symmetry [PDF]

, 2016
We study aspects of Heterotic/F-theory duality for compactifications with Abelian discrete gauge symmetries. We consider F-theory compactifications on genus-one fibered Calabi-Yau manifolds with n-sections, associated with the Tate-Shafarevich group Z_n.
Cvetic, Mirjam, Grassi, Antonella, Poretschkin, Maximilian   +2 more
core   +3 more sources

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

FEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli, Alex Fissore, Edoardo Salladini, Eleonora Raccuia, Simonetta Oliaro‐Bosso, Alessia Ruggiero, Rita Berisio, Milagros Medina, Adrian Velazquez‐Campoy, Salvatore Adinolfi, Mauro Marengo   +10 more
wiley   +1 more source

Heterotic-Type II duality in the hypermultiplet sector

, 2012
We revisit the duality between heterotic string theory compactified on K3 x T^2 and type IIA compactified on a Calabi-Yau threefold X in the hypermultiplet sector.
A Ceresole, A Collinucci, A Klemm, A Strominger, B Pioline, B Wit de, B Wit de, B Wit de, C Angelantonj, CG Callan Jr, CM Hull, D Gaiotto, D Robles-Llana, D Robles-Llana, D Robles-Llana, DR Morrison, DR Morrison, E Witten, E Witten, E Witten, G Lopes Cardoso, H Günther, I Antoniadis, I Antoniadis, I Antoniadis, I Antoniadis, J Bagger, J Louis, J Louis, J Louis, J Louis, J Louis, JA Harvey, Jan Louis, L Andrianopoli, M Haack, M Rozali, MJ Duff, MJ Duff, N Halmagyi, N Seiberg, P Candelas, P Mayr, PS Aspinwall, PS Aspinwall, PS Aspinwall, PS Aspinwall, PS Aspinwall, R Friedman, R Valandro, Roberto Valandro, S Alexandrov, S Alexandrov, S Cecotti, S Ferrara, S Ferrara, S Kachru, S Kachru, V Kaplunovsky, W Lerche   +59 more
core   +1 more source

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

FEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász, Albert Bálint Papp, Lukács Sándor Lesinszki, Attila Mócsai, Tamás Varga, László Nagy, Péter Gogolák   +6 more
wiley   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

Molecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop, Edgar Cardenas De La Hoz, Hanne Verswyvel, Joey De Backer, Ho Wa Lau, Angela Privat‐Maldonado, Wim Vanden Berghe, Steve Vanlanduit, Evelien Smits, Annemie Bogaerts, Abraham Lin   +10 more
wiley   +1 more source

On S-duality for holographic p-wave superconductors

, 2017
We consider the generalization of the S-duality transformation previously investigated in the context of the FQHE and s-wave superconductivity to p-wave superconductivity in 2+1 dimensions in the framework of the AdS/CFT correspondence. The vector Cooper
Gorsky, Alexander, Gubankova, Elena, Meyer, Rene, Zayakin, Andrey   +3 more
core   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Gravitational Radiation from Color-Kinematics Duality

, 2018
We perturbatively calculate classical radiation in Yang-Mills theory and dilaton gravity, to next-to-leading order in couplings. The radiation is sourced by the scattering of two relativistic massive scalar sources with the dynamical effect taken into ...
Shen, Chia-Hsien
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source