Results 1 to 10 of about 13,513 (144)

Targeted recruitment of USP15 enhances CTLA4 surface levels and restricts its degradation [PDF]

Life Science Alliance
A comprehensive analysis of CTLA4 stabilisation by induced proximity of a DUB, provides a template for rigorous analysis of DUB:target pairings in the advancement of ENTAC development pipelines.
Francesca Querques, Victoria Ciampani, Pei Yee Tey, Victoria D Kutilek, Elma Kadic, Michael J Clague, Sylvie Urbé   +6 more
doaj   +3 more sources

Deubiquitination-related genes define immune subtypes of colorectal cancer and are associated with prognosis and immunotherapy-related signatures [PDF]

Scientific Reports
Colorectal cancer (CRC) is highly heterogeneous, and the contribution of deubiquitination (DUB) programs to immune context and clinical outcome remains incompletely defined. We integrated transcriptomes from TCGA and GTEx (COAD/READ) with an external GEO
Yiwei Xu, Zhiyong Mo, Qing Jiang, Jingjing Pan, Qi Xu, Juwen Jia   +5 more
doaj   +2 more sources

A percepção de duas professoras sobre as potencialidades do uso do vídeo “Soma 3” do MathLibras para o ensino de Matemática para crianças surdas

Revista de Investigação e Divulgação em Educação Matemática, 2023
A pesquisa aqui apresentada, síntese de uma dissertação, tem caráter qualitativo e define-se como um estudo de caso. Tem como objetivo analisar a potencialidade do uso do vídeo “Soma 3” para o ensino de Matemática para crianças surdas do 1º e do 2º ano ...
Melissa Novack Oliveira Ribeiro, Thais Philipsen Grutzmann, Tatiana Bolivar Lebedeff   +2 more
doaj   +1 more source

Ensinar e aprender multiplicação: uma proposta com alunos surdos

Tangram, 2022
O artigo é resultado de uma pesquisa de mestrado cujo objetivo foi compreender o processo de construção do conceito multiplicativo por um grupo de alunos surdos.
Thaís Philipsen Grützmann, Fabiane Carvalho Bohm, Tatiana Bolivar Lebedeff   +2 more
doaj   +1 more source

Hypoxia Inducible Factor-1 Alpha and Matrix Metalloproteinase-9 in Dysfunctional Uterine Bleeding [PDF]

Journal of Clinical and Diagnostic Research, 2022
Introduction: Dysfunctional Uterine Bleeding (DUB) is prevalent in 10-15% of gynaecological patients. Matrix Metallopeptidase-9 (MMP-9) expression is stimulated by reduced oxygen levels in a highly aggressive, metastatic breast cancer cell line, although
Ketki Khandhadiya, Mrinal Gupta, Shailesh Kumar   +2 more
doaj   +1 more source

Embryonic demise caused by targeted disruption of a cysteine protease Dub-2. [PDF]

PLoS ONE, 2012
BACKGROUND: A plethora of biological metabolisms are regulated by the mechanisms of ubiquitination, wherein this process is balanced with the action of deubiquitination system.
Kwang-Hyun Baek, Heyjin Lee, Sunmee Yang, Soo-Bin Lim, Wonwoo Lee, Jeoung Eun Lee, Jung-Jin Lim, Kisun Jun, Dong-Ryul Lee, Young Chung   +9 more
doaj   +1 more source

A Human DUB Protein Array for Clarification of Linkage Specificity of Polyubiquitin Chain and Application to Evaluation of Its Inhibitors

Biomedicines, 2020
Protein ubiquitinations play pivotal roles in many cellular processes, including homeostasis, responses to various stimulations, and progression of diseases.
Hirotaka Takahashi, Satoshi Yamanaka, Shohei Kuwada, Kana Higaki, Kohki Kido, Yusuke Sato, Shuya Fukai, Fuminori Tokunaga, Tatsuya Sawasaki   +8 more
doaj   +1 more source

Decylubiquinone Inhibits Colorectal Cancer Growth Through Upregulating Sirtuin2

Frontiers in Pharmacology, 2022
Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide. Decylubiquinone (DUb), a coenzyme Q10 analog, was reported to inhibit breast cancer growth and metastasis by us. However, the influence of DUb on CRC remains unclear.
Jinlian Li, Shuting Zheng, Ting Cheng, Yuanyuan Li, Xiaobin Mai, Guangchun Jiang, Yongxia Yang, Qianqian Zhang, Jiangchao Li, Lingyun Zheng, Lijing Wang, Cuiling Qi, Cuiling Qi   +12 more
doaj   +1 more source

Deubiquitination complex platform: A plausible mechanism for regulating the substrate specificity of deubiquitinating enzymes

Acta Pharmaceutica Sinica B, 2023
Deubiquitinating enzymes (DUBs) or deubiquitinases facilitate the escape of multiple proteins from ubiquitin‒proteasome degradation and are critical for regulating protein expression levels in vivo.
Yi-Zheng Fang, Li Jiang, Qiaojun He, Ji Cao, Bo Yang   +4 more
doaj   +1 more source

Effectiveness of levonorgestrel-IUD in abnormal uterine bleeding management and user satisfaction [PDF]

New Indian Journal of OBGYN
Background: The prevalence rate of abnormal uterine bleeding (AUB) in India is 17.9% which causes not only psychological and physical discomfort but also has ill effect on health status and quality of life.
Raviraj Khairnar, Archana Khairnar
doaj   +1 more source