Results 181 to 190 of about 13,612 (242)

Role of Ubiquitin-regulated EMT in Cancer Metastasis and Chemoresistance. [PDF]

Int J Biol Sci
Xiao S, Tian L, Gan X, Xu X, Liao M, Song D, Yu Y, Qin W, Zhang R, Lyu H, Guo D, Zhang Q, Chen XZ, Zhou C, Tang J.   +14 more
europepmc   +1 more source

Interactive Groupwise Comparison for Reinforcement Learning from Human Feedback

Computer Graphics Forum, EarlyView.
The standard RLHF uses pairwise comparisons and therefore requires a large number of comparisons leading to a high workload. The comparison pairs are suggested by the system and cannot be chosen by the user. Our RLHF approach provides more agency to the user and demands less work: we leverage the user's visual abilities to effectively explore the ...
Jan Kompatscher, Danqing Shi, Giovanna Varni, Tino Weinkauf, Antti Oulasvirta   +4 more
wiley   +1 more source

Single-cell RNA sequence analysis reveals USP32 as a therapeutic target to mitigate PD-L1-driven colorectal tumorigenesis <i>in vitro</i> and <i>in vivo</i>. [PDF]

Theranostics
Birappa G, Perumalsamy H, Hong SH, Gowda DAA, Chandrasekaran AP, Karapurkar JK, Rajkumar S, Balusamy SR, Jayachandran A, Baek KH, Lee J, Matam V, Kim WJ, Kim KS, Ramakrishna S, Suresh B.   +15 more
europepmc   +1 more source

Poor Children in Our School? Child Poverty‐Related Beliefs and Practices Among Primary School‐Based Professionals in Finland

Children &Society, EarlyView.
ABSTRACT Despite being viewed as highly equal welfare societies, child poverty remains an unsolved problem in the Nordic countries. This article investigates the various types of institutionalised, underlying beliefs about child poverty held by professionals working within the Finnish primary school system, and how these assumptions shape school ...
Christa Järvinen, Helena Blomberg, Christian Kroll   +2 more
wiley   +1 more source

Deubiquitinating Enzymes in Osteoarthritis: From Mechanisms to Therapeutic. [PDF]

Orthop Rev (Pavia)
Yuan Z, Chen G, Li Y, Zhao Z, Zhang H.
europepmc   +1 more source

Glucocorticoids and HPA axis regulation in the stress–obesity connection: A comprehensive overview of biological, physiological and behavioural dimensions

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Chronic stress, characterized by increased long‐term exposure to the glucocorticoid hormone cortisol, is increasingly linked to obesity development. Still, various knowledge gaps persist, including on underlying pathophysiological mechanisms. The aim of the current review is to provide the latest insights on the connection between stress and ...
Robin Lengton, Myrte Schoenmakers, Brenda W. J. H. Penninx, Mariëtte R. Boon, Elisabeth F. C. van Rossum   +4 more
wiley   +1 more source

Knockdown of PR-DUB subunit calypso in the developing Drosophila eye and wing results in mis-patterned tissues with altered size and shape. [PDF]

G3 (Bethesda)
Luf M, Begani P, Bowcock AM, Pfleger CM.
europepmc   +1 more source

Assessing the integration of social marketing principles in ivory demand management interventions in China and Southeast Asia

Conservation Biology, EarlyView.
Abstract Consumer demand for ivory perpetuates the unsustainable and illegal killing of African elephants and other wildlife species. Interventions that aim to change consumer behavior are increasingly recognized as a crucial element of demand management. However, poor design and implementation have limited their effectiveness.
Molly R. C. Brown, Victoria K. Wells, Colin M. Beale   +2 more
wiley   +1 more source

Therapeutic targeting of YOD1 disrupts the PAX-FOXO1/N-Myc feedback loop in rhabdomyosarcoma. [PDF]

JCI Insight
Ying W, Yu J, Wang X, Liu J, Deng B, Shao X, Wang J, Tao T, Cao J, He Q, Yang B, Chen Y, Ying M.   +12 more
europepmc   +1 more source

Should more teams “trust the process” of tanking?

Contemporary Economic Policy, EarlyView.
Abstract In many professional sport leagues, the worst‐performing teams receive higher probability of earning top draft picks. This provides teams incentives to purposefully lose, or “tank,” if they are not likely to contend for the playoffs or championships.
Eduardo G. Minuci, Alexander Cardazzi, Candon Johnson   +2 more
wiley   +1 more source