Results 111 to 120 of about 68,781 (284)

Elucidating the Role and Mechanism of Alpha‐Enolase in Senescent Amelioration via Metabolic Reprogramming

open access: yesCell Proliferation, EarlyView.
KB2764 interacted with alpha‐enolase (ENO1) and pyruvate kinase M (PKM), ultimately leading to PKM phosphorylation of ENO1. KB2764 consequently increased mitochondrial ATP production and decreased glycolysis dependence. Furthermore, the action of KB2764 extends its application to extend the lifespan of Caenorhabditis elegans.
Yun Haeng Lee   +13 more
wiley   +1 more source

Role of Histone Deacetylase and Inhibitors in Cardiovascular Diseases

open access: yesCell Proliferation, EarlyView.
HDACs play an important role in the occurrence and development of cardiovascular diseases, such as myocardial hypertrophy, hypertension, and atherosclerosis. HDAC inhibitors have broad prospects for the treatment of CVD, and different HDAC subtypes can act through different mechanisms.
Li‐Ying Zhang   +4 more
wiley   +1 more source

Noninvasive ventilatory support to reverse weight loss in Duchenne muscular dystrophy: A case series

open access: yesPulmonology, 2019
This case series of five patients with Duchenne muscular dystrophy demonstrates the nutritional advantages of instituting noninvasive intermittent positive pressure ventilatory support via 15 mm angled mouthpieces to relieve tachypnea and provide more ...
P. Deo, J.R. Bach
doaj  

Duchenne Muscular Dystrophy Newborn Screening: Evaluation of a New GSP® Neonatal Creatine Kinase-MM Kit in a US and Danish Population

open access: yesInternational Journal of Neonatal Screening, 2019
Duchenne muscular dystrophy (DMD/Duchenne) is a progressive X-linked disease and is the most common pediatric-onset form of muscular dystrophy, affecting approximately 1:5000 live male births. DNA testing for mutations in the dystrophin gene confirms the
Anne Timonen   +11 more
doaj   +1 more source

Parental perspectives on family‐centered care in pediatric neurology: An explanatory sequential mixed‐methods study

open access: yesDevelopmental Medicine &Child Neurology, EarlyView.
The proposed conceptual framework highlighting parents' central role in their child's healthcare experience. Abstract Aim To explore parents' experiences of family‐centered care (FCC) in a pediatric neurology clinic. Method In this explanatory sequential mixed‐methods study, parents of children with neurological conditions completed the Measure of ...
Ege Sarikaya   +21 more
wiley   +1 more source

Mental wellbeing in non-ambulant youth with neuromuscular disorders: What makes the difference? [PDF]

open access: yes, 2018
The physical and social challenges associated with neuromuscular disorders may impact mental wellbeing in non-ambulant youth during the more vulnerable period of adolescence.
Downs, Jenny   +4 more
core   +1 more source

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