Results 151 to 160 of about 1,556 (213)

Bilateral Prophylactic and Contralateral Risk‐Reducing Mastectomy in Women With Germline CDH1 Pathogenic or Likely‐Pathogenic Variants

Journal of Surgical Oncology, Volume 134, Issue 4, Page 475-480, September 15, 2026.
ABSTRACT Bilateral prophylactic mastectomy (BPM) or contralateral risk‐reducing mastectomy (CRRM) are considered in CDH1 carriers as a strategy to reduce lobular breast cancer (LBC) risk in women. In this study we aimed to evaluate the overall number of these procedures reported in literature.
Giovanni Corso, Carlo La Vecchia, Francesca Magnoni, Andrea Polizzi, Elisa Bottazzoli, Alessandra De Scalzi, Susanna Di Silvestre, Eleonora Meduri, Filippo Pesapane, Luca Nicosia, Francesca De Lorenzi, Mattia Intra, Viviana Galimberti, Paolo Veronesi   +13 more
wiley   +1 more source

Shear Wave Elastography for Characterization of Breast Lesions in Clinical Routine

Journal of Ultrasound in Medicine, Volume 45, Issue 9, Page 1833-1842, September 2026.
Objectives Breast cancer remains a major global health challenge, and conventional B‐mode ultrasound frequently encounters limitations in reliably distinguishing benign from malignant lesions, particularly within intermediate Breast Imaging‐Reporting and Data System (BI‐RADS) categories.
Sylvia Kelemen, Tician Schnitzler, Simin Laures, Daniela Schwegler‐Guggemos, Nikki Rommers, Sebastian Schindera, Michael Golatta   +6 more
wiley   +1 more source

Advances in FGF/FGFR Signaling: Implications for Disease and Therapy

MedComm, Volume 7, Issue 9, September 2026.
The FGF/FGFR signaling is indispensable for the maintenance of physiological homeostasis and governs multiple biological processes, including embryonic development, bone metabolism, angiogenesis, and neurogenesis, whereas aberrant hyperactivation of this pathway drives the progression of malignancies and autoimmune disorders, including inflammatory ...
Miaoyu Song, Xi Liu, Yang Xiao, Yongsheng Li, Huakan Zhao   +4 more
wiley   +1 more source

Abscopal Effect in Radiation Therapy: The Immune Mechanisms and Clinical Advances

MedComm, Volume 7, Issue 9, September 2026.
The schematic outlines the key events of the abscopal effect. (Ignition) Local radiotherapy (RT) induces the release of immunogenic signals from the tumor, leading to dendritic cell (DC) activation. (Orchestration) In the tumor‐draining lymph node (TDLN), DCs prime naive T cells into cytotoxic T lymphocytes (CTLs), a process modulated by regulatory T ...
Yihong Dong, Moran Chen, Xupeng Hou, Xiaoya Tang, Xiaoli Yu, Jing Liu   +5 more
wiley   +1 more source

RNA‐Binding Proteins: Function, Biological Mechanisms, and Therapeutic Opportunities

MedComm, Volume 7, Issue 9, September 2026.
RNA‐binding proteins (RBPs) regulate RNA stability, localization, translation, and splicing through intrinsic binding domains and interactions with diverse cellular partners. Their competitive and cooperative networks shape disease‐related RNA programs, especially in cancer.
Ling Li, Xiuli Yan, Qing Ji, Hui Zhang
wiley   +1 more source

High‐Content CRISPR Screening: Methods and Applications

MedComm, Volume 7, Issue 9, September 2026.
High‐content CRISPR screening represents a paradigm shift in functional genomics, moving beyond traditional survival‐based readouts to enable multidimensional mapping of genotype–phenotype relationships. This review systematically outlines the methodological evolution of this approach, detailing advances in perturbation modalities, delivery systems ...
Yike Zhang, Yimeng Zhang, Xudong Tang, Xinyu Deng, Yitian Zhou, Yanfeng Wu, Jianhua Luo   +6 more
wiley   +1 more source

Ductal carcinoma in situ

The Breast, 1998
openaire   +1 more source

Tissue‐Resident Macrophage in Inflammation and Cancer

MedComm, Volume 7, Issue 9, September 2026.
Opposing macrophage functions in inflammation and cancer converge on shared mechanistic nodes, informing cross‐disease therapeutic strategies. ABSTRACT Tissue‐resident macrophages (TRMs) are long‐lived immune cells strategically distributed across organs, where their functional plasticity enables both homeostatic maintenance and pathological ...
Siyuan Huang, Jiangbo Fan, Wenyi Liu, Di Liu, Rui Wang, Yuanyang Wang, Jianhui Sun, Huacai Zhang, Qingli Cai, Zhe Xu, Fang Xu, Jianxin Jiang, Zhen Wang, Ling Zeng   +13 more
wiley   +1 more source

Microbial Signals in Cancer: Dissecting Host–Microbiota–Tumor Interactions and Potential Therapeutic Strategy

MedComm, Volume 7, Issue 9, September 2026.
Microbial signals from gut and tumor‐resident bacteria, fungi, viruses, and bacteriophages reshape immune and metabolic networks within the tumor microenvironment, thereby influencing cancer progression, treatment response. Therapeutic modulations, including dietary interventions, probiotics, antibiotics, fecal microbiota transplantation, engineered ...
Juan Lu, Mengjuan Xuan, Liang Yu, Zhongyang Xie, Qingfei Chu, Shihui Wei, Tuokai Wang, Chen Xue, Lanjuan Li   +8 more
wiley   +1 more source

Apolipoprotein E DNA Methylation Linked to Cognitive Decline in Postmenopausal Women With Breast Cancer

Molecular Genetics &Genomic Medicine, Volume 14, Issue 9, September 2026.
Apolipoprotein E (APOE) DNA methylation was associated with cognitive performance in postmenopausal women with breast cancer, with patterns differing by APOE4 status and exercise participation. Exercise appeared to improve cognitive performance among women with higher APOE DNA methylation, suggesting a possible buffering effect on adverse epigenetic ...
Emily K. Mewborn, Lacey W. Heinsberg, Myeong‐ga Cho, Kirk I. Erickson, Catherine M. Bender, Yvette P. Conley   +5 more
wiley   +1 more source